Results 1 to 10 of about 86,100 (300)
Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment. [PDF]
PLoS ONE, 2009 BACKGROUND:Lethal mutagenesis, or virus extinction promoted by mutagen-induced elevation of mutation rates of viruses, may meet with the problem of selection of mutagen-resistant variants, as extensively documented for standard, non-mutagenic antiviral ...
Celia Perales +2 more
doaj +5 more sources
Exploring the Utility of <i>Prunus mahaleb</i> Extracts as a Source of Natural Bioactive Compounds for Functional Applications. [PDF]
Food Sci NutrOur findings indicate that P. mahaleb can serve as a versatile raw material for the development of health‐promoting applications, including medicines, cosmeceuticals, and nutraceuticals. ABSTRACT Prunus mahaleb has garnered attention as a potent medicinal agent and functional component.
Atasagun B +6 more
europepmc +2 more sources
Arenaviruses and Lethal Mutagenesis. Prospects for New Ribavirin-based Interventions [PDF]
Viruses, 2012 Lymphocytic choriomeningitis virus (LCMV) has contributed to unveil some of the molecular mechanisms of lethal mutagenesis, or loss of virus infectivity due to increased mutation rates.
Ana Grande-Pérez +3 more
doaj +2 more sources
Cyto-Genotoxic Assessment of Sulfoxaflor in Allium cepa Root Cells and DNA Docking Studies. [PDF]
Microsc Res TechCyto‐genotoxic Assessment of Sulfoxaflor in Allium cepa Root Cells and DNA Docking Studies. ABSTRACT Sulfoxaflor (SFX) is an insecticide that is commonly used for the control of sap‐feeding insects. Since SFX is extensively applied globally, it has been implicated in the substantial induction of environmental toxicity.
Liman R +7 more
europepmc +2 more sources
Agriculture, 2023 Wheat, which is scientifically known as Triticum aestivum L., is a very nutritious grain that serves as a key component of the human diet. The use of mutation breeding as a tool for crop improvement is a reasonably rapid procedure, and it generates a ...
Aras Türkoğlu +10 more
doaj +1 more source
Agronomy, 2022 The shoot and fruit borer has asserted itself as a severe pest of eggplant. In vitro mutagenesis is an excellent method for producing mutants resistant to biotic and abiotic stresses.
Md Ashraful Islam +5 more
doaj +1 more source
Favipiravir Suppresses Zika Virus (ZIKV) through Activity as a Mutagen
Microorganisms, 2023 In a companion paper, we demonstrated that the nucleoside analogue favipiravir (FAV) suppressed Zika virus (ZIKV) replication in three human-derived cell lines—HeLa, SK-N-MC, and HUH-7.
Evelyn J. Franco +5 more
doaj +1 more source
Environmental and Molecular Mutagenesis, Volume 63, Issue 8-9, Page 376-388, December 2022., 2022 Abstract The OECD Test Guideline 488 (TG 488) for the Transgenic Rodent Gene Mutation Assay has undergone several revisions to update the recommended design for studying mutations in somatic tissues and male germ cells. The recently revised TG recommends a single sampling time of 28 days following 28 days of exposure (i.e., 28 + 28 days) for all ...
George R. Douglas +9 more
wiley +1 more source
In vivo and in vitro random mutagenesis techniques in plants
EFSA Journal, 2021 Mutations are changes in the genetic material that may be transmitted to subsequent generations. Mutations appear spontaneously in nature and are one of the underlying driving forces of evolution. In plants, in vivo and in vitro random mutagenesis relies
EFSA Panel on Genetically Modified Organisms (GMO) +20 more
doaj +1 more source
Frontiers in Veterinary Science, 2023 IntroductionThe antiviral activity of different mutagens against single-stranded RNA viruses is well documented; however, their activity on the replication of double-stranded RNA viruses remains unexplored.
Towseef Akram +13 more
doaj +1 more source