Results 101 to 110 of about 86,136 (325)

Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: A model for identifying candidate breast-tumor suppressors

open access: yesMolecular Cancer, 2008
BackgroundWidely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation.
Helena Zientek-Targosz   +6 more
semanticscholar   +1 more source

Environmental Drivers of Malignant Clonal Selection in Precancerous Lesion Evolution

open access: yesCell Proliferation, EarlyView.
ABSTRACT Somatic mutations accumulation and subsequent malignant clonal selection are the processes that lead to cancer. The intricacy includes exposure to carcinogens as well as the ways in which these exposures interact with genetic, polygenic, or epigenetic predispositions.
Yancheng Lai, Shaosen Zhang
wiley   +1 more source

UV Radiation and the Skin

open access: yesInternational Journal of Molecular Sciences, 2013
UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter.
J. D'Orazio   +3 more
semanticscholar   +1 more source

Photodynamic therapy of cancer‐associated infections

open access: yesPhotochemistry and Photobiology, EarlyView.
Pathogens can be involved in tumor initiation, promotion and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor‐prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections, and, therefore, has a unique potential to address ...
Giulia Kassab, Juan Chen, Gang Zheng
wiley   +1 more source

The Drought-Stress Response of a Drought Resistant Impatiens Processed in PEG-6000 Solution in a Simulation Test [PDF]

open access: yesarXiv, 2016
Premise of the Study: Impatiens is a commonly seen garden flower, renowned for its strong adaptability and long history of cultivation. However, seldom has any research touched on its physiological resistance mechanism. In this experiment, the impatiens is selected from those which experienced aerospace mutation and thereafter 12 years of cultivation ...
arxiv  

Determination of optimum dose of chemical mutagen for large scale seed treatment of white seeded sesame (Sesamum indicum L.) varieties

open access: yesElectronic Journal of Plant Breeding, 2020
In the present study two white seeded sesame varieties VRI 3 and SVPR 1 were treated with seven different concentration viz., 0.2 %, 0.4 %, 0.6 %, 0.8 %, 1 %, 1.2 % and 1.4 % of chemical mutagen Ethyl Methane Sulphonate (EMS).
V. Sandhiya, M. Kumar, C. Parameswari, C. Vanniarajan, N. Kumaravadivel, N. Sakthivel and Anand M. Badigannavar
doaj   +1 more source

Food Mutagens [PDF]

open access: yesThe Journal of Nutrition, 2003
Several lines of evidence indicate that diet and dietary behaviors can contribute to human cancer risk. One way that this occurs is through the ingestion of food mutagens. Sporadic cancers result from a gene-environment interactions where the environment includes endogenous and exogenous exposures.
Radoslav, Goldman, Peter G, Shields
openaire   +2 more sources

Exploring the multifaceted dynamics of flowering time regulation in field crops: Insight and intervention approaches

open access: yesThe Plant Genome, Volume 18, Issue 2, June 2025.
Abstract The flowering time (FTi) plays a critical role in the reproductive success and yield of various crop species by directly impacting both the quality and quantity of grain yield. Achieving optimal FTi is crucial for maximizing reproductive success and ensuring overall agricultural productivity.
Yogesh Dashrath Naik   +17 more
wiley   +1 more source

Using Rigidity Analysis to Probe Mutation-Induced Structural Changes in Proteins [PDF]

open access: yes, 2012
Predicting the effect of a single amino acid substitution on the stability of a protein structure is a fundamental task in macromolecular modeling. It has relevance to drug design and understanding of disease-causing protein variants.
Hardy, Jeanne   +2 more
core   +1 more source

Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster

open access: yesJournal of Applied Toxicology, Volume 45, Issue 5, Page 841-857, May 2025.
ABSTRACT N‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as a potent hepatotoxin, promutagen, and probable human carcinogen; this is because of the metabolites associated with its biotransformation. The metabolism of NDMA produces formaldehyde, another alkylating agent and DBP. Both compounds are generated from
Oscar Eduardo Tabares‐Mosquera   +3 more
wiley   +1 more source

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