Results 51 to 60 of about 26,667 (223)
The Journal of Nutrition, 2003 Several lines of evidence indicate that diet and dietary behaviors can contribute to human cancer risk. One way that this occurs is through the ingestion of food mutagens. Sporadic cancers result from a gene-environment interactions where the environment includes endogenous and exogenous exposures.
Radoslav, Goldman, Peter G, Shields
openaire +2 more sources
Optimal Control of Evolutionary Dynamics [PDF]
arXiv, 2008 Elucidating the fitness measures optimized during the evolution of complex biological systems is a major challenge in evolutionary theory. We present experimental evidence and an analytical framework demonstrating how biochemical networks exploit optimal control strategies in their evolutionary dynamics.
arxiv
Determination of absorption dose in chemical mutagenesis in plants.
PLoS ONE, 2019 Chemical mutagenesis is a useful tool for inducing mutations in plants. Seeds are often used as the material for chemical mutagenesis. The biological effect of a chemical mutagen on seeds is determined by absorption dose (the product of mutagen ...
Changjiao Ke +7 more
doaj +1 more source
Solution of the Quasispecies Model for an Arbitrary Gene Network [PDF]
, 2004 In this paper, we study the equilibrium behavior of Eigen's quasispecies equations for an arbitrary gene network. We consider a genome consisting of $ N $ genes, so that each gene sequence $ \sigma $ may be written as $ \sigma = \sigma_1 \sigma_2 ... \sigma_N $.
arxiv +1 more source
Agricultura, 2008 PHENOTIPICAL AND CITOLOGICAL MODIFICATIONS AT SAINFOIN (Onobrychis viiifolia Scop) TREATED WITH GAMMA RAYS In order to make the experiences it was used the “Splendid” sainfoin cultivar, created at USAMV Cluj. To induce the mutations there were used
Elena TĂMAŞ, R. SESTRAŞ, P. RAICA
doaj +1 more source
A mathematical model of DNA degradation: Possible role of magnetic nanoparticles [PDF]
arXiv, 2007 A mathematical model of genome degradation is proposed that takes into account a variable rate of mutation and increasing number of cells in a developing human organism. The model explains known properties of cancer development, in particular, a synergism between different mutagens and an increased probability of cancer in the early years of life.
arxiv
Micronucleus induction by 915 MHz Radiofrequency Radiation in Vicia faba root tips [PDF]
arXiv, 2014 The mutagenic effect of radiofrequency electromagnetic field (RF-EMF) is evaluated by the micronucleus (MN) test in secondary roots of Vicia faba seedlings. Root exposures were carried out with 915 MHz continuous wave (CW) radiation for 72h, at power densities of 25, 38, 50 W/m$^2$.
arxiv
Dynamics and bifurcations in a simple quasispecies model of tumorigenesis [PDF]
arXiv, 2014 Cancer is a complex disease and thus is complicated to model. However, simple models that describe the main processes involved in tumoral dynamics, e.g., competition and mutation, can give us clues about cancer behaviour, at least qualitatively, also allowing us to make predictions.
arxiv
The human, F-actin-based cytoskeleton as a mutagen sensor
Cancer Cell International, 2017 Background Forty years ago the actin cytoskeleton was determined to be disrupted in fibroblasts from persons with DNA repair-defective, hereditary colon cancer, with no clear connection between the cytoskeleton and DNA repair defects at that time ...
Nicolette M. Clark +12 more
doaj +1 more source
Interpreting the dependence of mutation rates on age and time [PDF]
arXiv, 2015 Mutations can arise from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing a framework for understanding how mutation rates depend on sex, age and absolute time. We show that
arxiv