Results 81 to 90 of about 86,136 (325)

Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The benchmark dose (BMD) approach constitutes the most effective and pragmatic strategy for the derivation of a point of departure (PoD) for comparative potency analysis, risk assessment, and regulatory decision‐making. There is considerable controversy regarding the most appropriate benchmark response (BMR) for genotoxicity endpoints.
Paul A. White   +8 more
wiley   +1 more source

EFFECT OF ROCKET JUICE (ERUCA SATIVA ) ON MITOTIC INDEX AND FORMATION OF MICRONUCLEI IN FEMUR BONE MARROW CELLS OF WHITE MICE [PDF]

open access: yesMesopotamia Journal of Agriculture, 2008
The effect of orally administered rocket leafs juice on the mitotic index (MI) and micronuclei (Mn) formation was studied in white mice bone marrow . The effect of juice to retarded the abnormalities induced by cyclophosphamide (Cp) administered orally ...
Ilham A. Khalaf
doaj   +1 more source

An Enhanced Metabolization Protocol for In Vitro Genotoxicity Assessment of N‐Nitrosamines in Mammalian Cells

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT N‐Nitrosamines (NAs) are probable human carcinogens and were detected as impurities in pharmaceuticals, which led to a concern for human health. NAs require metabolic activation before they become mutagenic, and not all NAs are mutagenic since their reactivity is related to their structure.
M. E. Geijer   +4 more
wiley   +1 more source

Chromosomal rearrangements caused by gamma-irradiation in winter wheat cells

open access: yesBiosystems Diversity, 2017
In this article we report the results of our investigation into several cytogenetic parameters of variability in mutation induction of modern winter wheat varieties and some connections between the means of cytogenetic indices and different doses of ...
M. M. Nazarenko, O. O. Izhboldin
doaj   +1 more source

Mutagen sensitivity, tobacco smoking and breast cancer risk: a case-control study.

open access: yesCarcinogenesis, 2010
UNLABELLED Given the high incidence of breast cancer and that more than half of cases remain unexplained, the need to identify risk factors for breast cancer remains. Deficiencies in DNA repair capacity have been associated with cancer risk.
O. Kosti   +9 more
semanticscholar   +1 more source

Genome Editing Technologies to Improve Health‐Related Phytocompounds in Crops

open access: yesFood Frontiers, EarlyView.
ABSTRACT Due to rapid global population growth and the resulting significant increase in food demand, the world is facing an epidemic of malnutrition. Although yield improvement remains one of the main targets of breeding programs, much attention is being paid to the nutritional aspects of crops, including nutrients and bioactive compounds that are ...
Maria Dellino   +4 more
wiley   +1 more source

Mutation Breeding in Ornamentals

open access: yesHortScience, 2021
The promising possibilities of mutation breeding in ornamental plants have led to a great interest in effective mutagenic treatment protocols for various species.
Killian Melsen   +2 more
doaj   +1 more source

Squamous cell carcinoma of the dorsal hands and feet after repeated exposure to ultraviolet nail lamps [PDF]

open access: yes, 2020
Gel nails are a common artificial nail option. Ultraviolet (UV) nail lamps are commonly used to cure gel nails. Ultraviolet A radiation is a known mutagen that penetrates into the nail bed.
Curtis, Julia   +3 more
core  

Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer

open access: yesCarcinogenesis, 2008
Aromatic amines, N-nitroso compounds and heterocyclic amines are suspected human pancreatic carcinogens. Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens.
Hideo Suzuki   +11 more
semanticscholar   +1 more source

Efficacy of Haloxyfop‐R‐Methyl on Allium cepa: Cyto‐Genotoxic and In Silico Docking Studies on the Mechanism of Action

open access: yesMicroscopy Research and Technique, EarlyView.
ABSTRACT Haloxyfop‐R‐methyl (HRM) is extensively employed to control annual and perennial grass weeds. This study aimed to investigate the cyto‐genotoxic effects of HRM at concentrations of 1.19, 2.38, and 4.76 mg/L over various time intervals (24, 48, 72, and 96 h) on Allium cepa root.
Recep Liman   +4 more
wiley   +1 more source

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