Results 221 to 230 of about 53,897 (283)

Quantitative mammalian cell mutagenesis and mutagen screening: study with CHO cells

, 1979
Abraham W. Hsie, John P. O’Neill, Juan Sebastián, Patricia A. Brimer   +3 more
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Inducing Potential Mutants in Bread Wheat Using Different Doses of Certain Physical and Chemical Mutagens

, 2020
Mutation is an effective strategy not only for creating novel variation into crop genome but also for direct releasing adapted and high-yielding genotypes.
Ghada Abaza, H. Awaad, Zakaria Attia, K. Abdel-Lateif, M. Gomaa, Safy M. Sh. M. Abaza, E. Mansour   +6 more
semanticscholar   +1 more source

Photoactivation of mutagens

Carcinogenesis, 1989
Solutions of several promutagens or of non-genotoxic carcinogens were exposed to sunlight or to artificial sources of UV or fluorescent light, under various experimental conditions. Irradiation resulted in the oxygen-mediated formation of direct-acting mutagenic and DNA-damaging photoproducts in bacteria, with evident structure-activity relationship ...
DE FLORA, SILVIO, CAMOIRANO, ANNA FIORENZA, IZZOTTI, ALBERTO, D'AGOSTINI, FRANCESCO, BENNICELLI, CARLO   +4 more
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Elevated Exposures to Polycyclic Aromatic Hydrocarbons and Other Organic Mutagens in Ottawa Firefighters Participating in Emergency, On-Shift Fire Suppression.

Environmental Science and Technology, 2017
Occupational exposures to combustion emissions were examined in Ottawa Fire Service (OFS) firefighters. Paired urine and dermal wipe samples (i.e., pre- and post-event) as well as personal air samples and fire event questionnaires were collected from 27 ...
J. Keir, U. Akhtar, David M J Matschke, T. Kirkham, H. Chan, P. Ayotte, P. White, J. Blais   +7 more
semanticscholar   +1 more source

Mutagenicity and co-mutagenicity of catechol on salmonella

Mutation Research Letters, 1983
Catechol was not mutagenic for Salmonella typhimurium TA98, TA100 or TA1537 in the presence or absence of S9 mix. At the lower level of S9 in the Ames method, the mutagenic activity of benzo[a]pyrene decreased with the increased addition of catechol.
Daisuke Yoshida, Yōko Fukuhara
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On the mutagenicity of nitrofurans

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1974
Summary 22 nitrofurans were tested for ability to induce revertants of E. coli WP2 and its uvrA - derivative from tryp - to tryp +. All proved to be mutagnic while two furan analogues (lacking the nitro- group) proved to be inactive. Test strains containing exrA - or recA - genes were not induced to mutate, suggesting that mutants arise in the
Donna Voutsinos, D.R. McCalla
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Mutagenicity of sulphonylureas

Mutation Research/Genetic Toxicology, 1980
The 11 derivatives of beta-cytotropic sulphonylureas commonly used in the treatment of diabetes mellitus were tested in vivo in the highly sensitive sister-chromatid exchange test. Chlorpropamide and tolbutamide gave a positive reaction with a clear dose-response in Chinese hamsters and mice.
Ruth Münzner, H.W. Renner
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Structure-activity relationships and design of viral mutagens and application to lethal mutagenesis.

Journal of Medicinal Chemistry, 2013
While mutation is the driving force behind evolution, most mutations are detrimental; therefore, elevating the mutation rate of a virus should diminish fitness.
L. Bonnac, L. Mansky, S. Patterson
semanticscholar   +1 more source

CHEMICAL MUTAGENS: PRINCIPLES AND METHODS FOR THEIR DETECTION

, 1972
INDUSTRIALIZATION and scientific progress have brought great benefits to mankind and many problems. To consider one aspect, the toxic efrects of bacteria and viruses are now insignificant problems compared with what they were a hundred years ago, but ...

semanticscholar   +1 more source

Caffeine and other methylxanthines as interceptors of food-borne aromatic mutagens: inhibition of Trp-P-1 and Trp-P-2 mutagenic activity.

Chemical Research in Toxicology, 2013
Caffeine is one of the most important biologically active food components. In this article, we demonstrate that caffeine and other methylxanthines significantly reduce the mutagenic activity of two food-derived heterocyclic aromatic amines, Trp-P-1 and ...
A. Woziwodzka, G. Gołuński, D. Wyrzykowski, R. Kazmierkiewicz, J. Piosik   +4 more
semanticscholar   +1 more source