Results 311 to 320 of about 1,312,216 (336)

UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities. [PDF]

RNA
Nasif S, Eberle AB, Schranz K, Hadorn R, Chakrabarti S, Mühlemann O.   +5 more
europepmc   +1 more source

A Charge-reversal Point Mutation Completely Depletes Flavin Chromophore from European Robin Cryptochrome 4a Protein

Xu J, Rasmussen ES, Berthias F, Schmidt J, Mouritsen H, Jensen ON, Solov’yov IA.   +6 more
europepmc   +1 more source

Stability of mutant p53 proteins

Stability of mutant p53 proteins
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Glassy dynamics in mutant huntingtin proteins

The Journal of Chemical Physics, 2018
Causative to the neurodegenerative Huntington’s disease (HD), a mutational huntingtin (HTT) protein consists of an unusual expansion on the poly-glutamine (polyQ) region in the first exon (exon-1) domain. Despite its significance on HD progression, the structural role of the exon-1 with the polyQ region is still elusive.
Hongsuk Kang, Binquan Luan, Ruhong Zhou
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Site-directed mutants of the cAMP receptor protein-DNA binding of five mutant proteins

"Protein Engineering, Design and Selection", 1987
Oligonucleotide-directed mutagenesis was employed to generate mutants of the cAMP receptor protein (CRP) of Escherichia coli. The mutant proteins were purified to homogeneity and tested for stability and DNA binding. It is shown that mutations at the position of Arg180 abolish specific DNA binding, whereas those at the position Arg185 have very little ...
M E, Gent, S, Gärtner, A M, Gronenborn, R, Sandulache, G M, Clore   +4 more
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Mutants for rice storage proteins

Theoretical and Applied Genetics, 1989
Rice storage proteins of the endosperm are localized in two types of protein bodies, PB-I and PB-II. Protein bodies were isolated by sucrose density gradient centrifugation from developing endosperm of three rice mutants, CM 21, CM 1675 and CM 1834, and characterized after pepsin-digestion treatment by protein contents determination.
M, Ogawa, T, Kumamaru, H, Satoh, T, Omura, T, Park, K, Shintaku, K, Baba   +6 more
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Applications of Protein Thermodynamic Database for Understanding Protein Mutant Stability and Designing Stable Mutants

2016
Protein stability is the free energy difference between unfolded and folded states of a protein, which lies in the range of 5-25 kcal/mol. Experimentally, protein stability is measured with circular dichroism, differential scanning calorimetry, and fluorescence spectroscopy using thermal and denaturant denaturation methods. These experimental data have
M Michael, Gromiha, P, Anoosha, Liang-Tsung, Huang   +2 more
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Computational approaches for predicting mutant protein stability

Journal of Computer-Aided Molecular Design, 2016
Mutations in the protein affect not only the structure of protein, but also its function and stability. Prediction of mutant protein stability with accuracy is desired for uncovering the molecular aspects of diseases and design of novel proteins. Many advanced computational approaches have been developed over the years, to predict the stability and ...
Shweta, Kulshreshtha, Vigi, Chaudhary, Girish K, Goswami, Nidhi, Mathur   +3 more
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Purification of recombinant C-reactive protein mutants

Journal of Immunological Methods, 2017
C-reactive protein (CRP) is an evolutionarily conserved protein, a component of the innate immune system, and an acute phase protein in humans. In addition to its raised level in blood in inflammatory states, CRP is also localized at sites of inflammation including atherosclerotic lesions, arthritic joints and amyloid plaque deposits.
Avinash Thirumalai, Sanjay K. Singh, David J. Hammond, Toh B. Gang, Donald N. Ngwa, Asmita Pathak, Alok Agrawal   +6 more
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