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International Journal of Computer Mathematics, 2011
We propose mutation systems as a model of the evolution of a string subject to the effects of mutations and a fitness function. One fundamental question about such a system is whether knowing the rules for mutations and fitness, we can predict whether it is possible for one string to evolve into another.
Dana Angluin +2 more
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We propose mutation systems as a model of the evolution of a string subject to the effects of mutations and a fitness function. One fundamental question about such a system is whether knowing the rules for mutations and fitness, we can predict whether it is possible for one string to evolve into another.
Dana Angluin +2 more
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Mutation and Mutation Screening
2013Molecular techniques have created the opportunity for great advances in plant mutation genetics and the science of mutation breeding. The powerful targeted induced local lesions in genomes (TILLING) technique has introduced the possibility of reverse genetics-the ability to screen for mutations at the DNA level prior to assessing phenotype. Fundamental
Lee, L Slade +4 more
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Software Testing, Verification and Reliability, 2001
AbstractApplications that utilize a broker‐based architecture are often composed of components that need to be tested individually and in combination. Furthermore, adequacy assessment of tests of components is useful in that it assists testers in identifying weaknesses in the tests generated so far and in offering hints on what the new tests must be ...
Sudipto Ghosh 0001, Aditya P. Mathur
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AbstractApplications that utilize a broker‐based architecture are often composed of components that need to be tested individually and in combination. Furthermore, adequacy assessment of tests of components is useful in that it assists testers in identifying weaknesses in the tests generated so far and in offering hints on what the new tests must be ...
Sudipto Ghosh 0001, Aditya P. Mathur
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Microsatellite instability: The mutator that mutates the other mutator
Nature Medicine, 1996Microsatellite mutations are useful markers of both tumor clonality and genomic instability but the origin of the mutator mutations responsible is still not well understood (pages 676–681).
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Characterization of the mutator mutation mut5-1
Molecular and General Genetics MGG, 1979The mutator mutation mut5-1 has been characterized with respect to a range of parameters which have been used to describe DNA repair mutants of yeast. No marked effect of the mutation on UV-mutability at lower doses was apparent. Diploids homozygous for the mutation are deficient in UV-induced recombination between the alleles his1-1 and hist1-315 ...
D P, Morrison, P J, Hastings
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Mutation Detection and Mutation Databases
cclm, 1998AbstractDetection of mutations in genes is vital throughout biology, however, this activity is time-consuming, expensive and requires a high degree of skill. This is unsatisfactory in a field which is increasing importance. Around 10–12 methods are commonly used with some predominating.
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Nature, 1991
The detection and characterization of mutations in genes has become a major area of interest in many areas of biology. Such variation may account for speciation, tumour formation, drug resistance, as well as the more obvious nature of inherited disease.
R G, Cotton, A D, Malcolm
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The detection and characterization of mutations in genes has become a major area of interest in many areas of biology. Such variation may account for speciation, tumour formation, drug resistance, as well as the more obvious nature of inherited disease.
R G, Cotton, A D, Malcolm
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Directional mutation pressure, mutator mutations, and dynamics of molecular evolution
Journal of Molecular Evolution, 1993Using a general form of the directional mutation theory, this paper analyzes the effect of mutations in mutator genes on the G+C content of DNA, the frequency of substitution mutations, and evolutionary changes (cumulative mutations) under various degrees of selective constraints.
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