Results 91 to 100 of about 87,531 (297)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Induction of short stature and early maturity in lentil (Lens culinaris Medik.) through mutagenesis

Journal of Agriculture and Natural Resources
Induced mutagenesis is a pivotal tool for enhancing the genetic diversity and achieving targeted trait selection in pulse crops. In M2 and M3 generations of lentil (Lens culinaris Medik, var.
Rafiul Amin Laskar, Mohammad Rafiq Wani, Roshan Jahan, Samiullah Khan   +3 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Loss of susceptibility as a novel breeding strategy for durable and broad-spectrum resistance [PDF]

, 2010
Recent studies on plant immunity have suggested that a pathogen should suppress induced plant defense in order to infect a plant species, which otherwise would have been a nonhost to the pathogen. For this purpose, pathogens exploit effector molecules to
Visser, R.G.F., JACOBSEN E, VISSER RGF, Jacobsen, E., Pavan, S.N.C., Bai, Y., BAI Y., PAVAN, STEFANO   +7 more
core   +1 more source

Comparative analysis of aroma components and quality of Geotrichum candidum after space mutation breeding. [PDF]

Front Microbiol, 2022
Chen J, Li Q, Wang J, Chen W, Zheng Q, Zhong Q, Fang X, Liao Z.   +7 more
europepmc   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

The effect of the ‘Gait keeper’ mutation in the DMRT3 gene on gaiting ability in Icelandic horses

, 2014
A nonsense mutation in DMRT3 (‘Gait keeper' mutation) has a predominant effect on gaiting ability in horses, being permissive for the ability to perform lateral gaits and having a favourable effect on speed capacity in trot. The DMRT3 mutant allele
Lindgren, Gabriella,, Sveriges lantbruksuniversitet., Andersson, Lisa,, Björnsdóttir, Sigridur,   +3 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Rice mutation breeding

, 2014
誘變爲增加遠傳變異的常用方法之一，過去在水稻的產量育種增進上，此方法曾經研發出相當的有用性狀；近年來在分子生物技術迅速進展及稻米品質改良與創新的發展趨勢下，誘變之創造特殊而多樣化性狀的能力又受到遺傳與育種界的重視。本文主要針對水稻輻射誘變育種、水稻化學物質誘變育種及綉變育種的實際操作等三個課題進行歸納與整理，其中水稻輻射誘變育種分別就輻射誘的原理及方法及水稻利 用輻射誘變育種的现況等研究成果加以論述；而化學物質誘變育種則討論化學誘變劑及其反應、化學誘變剤誘變育種的現況及誘變方法等三個課題 ...
Yong-Pei Wu Huu-Sheng Lur, 吳永培;盧虎生   +1 more
core