Results 141 to 150 of about 87,531 (297)
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
Advances in plant mutation breeding
, 2015 Die Nachhaltigkeit der weltweiten Landwirtschaft wird durch Bevölkerungswachstum, geringere Verfügbarkeit von Anbauflächen und Klimaveränderungen bedroht.
Bado, Souleymane
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Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Advanced Science, EarlyView.Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
Induced Mutation and Breeding Method in Fruit Trees
, 2012 果樹作物因育種上之特殊性、困難性，果樹誘變在果樹育種上備受矚目。果樹因樹體大，幼年期長，及世代交替不易，致傳統之果樹育種方法，很難在短期內育成經濟栽培品種。果樹誘變在縮短果樹育種年限上，有其特殊之效果。事實上，現有重要果樹中，有許多均源自於自然變異或實生選育，及人為誘變。人為誘變技術研究之不斷進行，尤其生物技術之發展，對期待人為突變體之育成，在果樹育種上將扮演重要的角色。本文將記述介紹果樹誘變與果樹育種之一體兩面，探討幾種果實際進行誘變育種之概況。 Breeders of fruit species ...
Min-syang Chen, 陳敏祥
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Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Research internship on mutation breeding at the Philippine Nuclear Research Institute (PNRI)
, 2010 Mutation are sudden heritable changes in an organism\u27s genetic material regarded as detrimental alternatives in plant breeder\u27s search for novel traits that can be useful in his crop improvement program.
Nuñez, John Paolo P
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Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
Effect of r-ray on the Growth of Poinsettia
, 2014 以γ-射線照射聖誕紅的插穗、發根苗及盆苗，期能誘發雙異，育成新品種。試驗使用'Peterstar'打發根苗為材料，處理γ射線0、25、35、45、50及l00格雷(Gy)劑量之結果顯示，隨劑量增加而使根部之傷害嚴重，株高之生長抑制也愈明顯，超過45Gy則植株均不能成活。其中以25Gy劑量照射者變異率為3.5%，而35Gy劑量照射者變異率為2.3%。另以'Peterstar'插穗先行25Gy照射，經扦插4週發根完全後再行25Gy照射，則變異率增為6.7%。而''Peterstar ...
Chien Young Chu +5 more
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