Results 101 to 110 of about 14,999,742 (341)

Mutational Biases Influence Parallel Adaptation

bioRxiv, 2017
While mutational biases strongly influence neutral molecular evolution, the role of mutational biases in shaping the course of adaptation is less clear. Here we consider the frequency of transitions relative to transversions among adaptive substitutions.
A. Stoltzfus, David M. McCandlish
semanticscholar   +1 more source

Structural Effects of Oncogenic PI3Kα Mutations [PDF]

, 2010
Physiological activation of PI3Kα is brought about by the release of the inhibition by p85 when the nSH2 binds the phosphorylated tyrosine of activated receptors or their substrates. Oncogenic mutations of PI3Kα result in a constitutively activated enzyme that triggers downstream pathways that increase tumor aggressiveness and survival.
Sandra B, Gabelli, Chuan-Hsiang, Huang, Diana, Mandelker, Oleg, Schmidt-Kittler, Bert, Vogelstein, L Mario, Amzel   +5 more
openaire   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

ISOWN: accurate somatic mutation identification in the absence of normal tissue controls. [PDF]

, 2017
BackgroundA key step in cancer genome analysis is the identification of somatic mutations in the tumor. This is typically done by comparing the genome of the tumor to the reference genome sequence derived from a normal tissue taken from the same donor ...
Bartlett, John MS, Kalatskaya, Irina, McPherson, John D, Spears, Melanie, Stein, Lincoln, Trinh, Quang M   +5 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

High correlation between the turnover of nucleotides under mutational pressure and the DNA composition

BMC Evolutionary Biology, 2001
Background Any DNA sequence is a result of compromise between the selection and mutation pressures exerted on it during evolution. It is difficult to estimate the relative influence of each of these pressures on the rate of accumulation of substitutions.
Dudkiewicz Malgorzata, Nowicka Aleksandra, Mackiewicz Dorota, Mackiewicz Pawel, Kowalczuk Maria, Dudek Miroslaw R, Cebrat Stanislaw   +6 more
doaj   +1 more source

Allelic overload and its clinical modifier effect in Bardet-Biedl syndrome

npj Genomic Medicine, 2022
Bardet–Biedl syndrome (BBS) is an autosomal recessive ciliopathy characterized by extensive inter- and intra-familial variability, in which oligogenic interactions have been also reported.
Irene Perea-Romero, Carlos Solarat, Fiona Blanco-Kelly, Iker Sanchez-Navarro, Brais Bea-Mascato, Eduardo Martin-Salazar, Isabel Lorda-Sanchez, Saoud Tahsin Swafiri, Almudena Avila-Fernandez, Inmaculada Martin-Merida, Maria Jose Trujillo-Tiebas, Ester Carreño, Belen Jimenez-Rolando, Blanca Garcia-Sandoval, Pablo Minguez, Marta Corton, Diana Valverde, Carmen Ayuso   +17 more
doaj   +1 more source

Mutation-Selection Balance: Ancestry, Load, and Maximum Principle

, 2002
We show how concepts from statistical physics, such as order parameter, thermodynamic limit, and quantum phase transition, translate into biological concepts in mutation-selection models for sequence evolution and can be used there.
Baake, Baake, Baake, Barton, Boerlijst, Bonhoeffer, Bürger, Bürger, Bürger, Bürger, Charlesworth, Crow, Crow, Demetrius, Demetrius, Eigen, Eigen, Eigen, Ellen Baake, Ethier, Ewens, Franz, Gabriel, Gabriel, Gillespie, Haldane, Hermisson, Higgs, Hofbauer, Hofbauer, Holger Wagner, Huynen, Jagers, Joachim Hermisson, Karlin, Karlin, Kauffman, Kauffman, Kesten, Kimura, Kimura, Kondrashov, Kondrashov, Leuthäusser, Leuthäusser, Maynard Smith, Moran, Nowak, O'Brien, Ohta, Ohta, Oliver Redner, Otto, Phillips, Sniegowski, Swetina, Swofford, Tarazona, Taylor, Wagner, Wagner, Wagner, Waxman, Wiehe, Wilkinson   +64 more
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Evolution of female choice and age-dependent male traits with paternal germ-line mutation

, 2013
Several studies question the adaptive value of female preferences for older males. Theory and evidence show that older males carry more deleterious mutations in their sperm than younger males carry.
Adamson, Joel James
core   +2 more sources