Results 241 to 250 of about 14,999,742 (341)

Aflatoxin Exposure, Chronic Hepatitis Infection, and HLA Diversity Converge to Shape Patient Survival in Hepatocellular Carcinoma. [PDF]

Cancer Epidemiol Biomarkers Prev
Guo Y, Jiang L, Alkali M, George SHL, Jones PD, Leng S, Ye F.   +6 more
europepmc   +1 more source

Neoadjuvant PD‐1 Blockade in Resectable Lung Cancer

New England Journal of Medicine, 2018
P. Forde, J. Chaft, Kellie N. Smith, V. Anagnostou, T. Cottrell, M. Hellmann, M. Zahurak, Stephen C. Yang, David R. Jones, S. Broderick, R. Battafarano, M. Velez, N. Rekhtman, Zachary T. Olah, J. Naidoo, K. Marrone, Franco Verde, Haidan Guo, Jiajia Zhang, J. Caushi, H. Chan, John-William Sidhom, R. Scharpf, J. White, E. Gabrielson, Hao Wang, G. Rosner, V. Rusch, J. Wolchok, T. Merghoub, J. Taube, V. Velculescu, S. Topalian, J. Brahmer, D. Pardoll   +34 more
semanticscholar   +1 more source

Network effects of disease mutations [PDF]

Nature Reviews Genetics, 2015
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Multi-omics profiling reveals microenvironmental remodeling as a key driver of house dust mite-induced lung cancer progression. [PDF]

Neoplasia
Al-Azzam S, Stuewe I, Sharma S, Yamada-Hara M, Tanaka A, Stringer K, Behnam M, Al-Azzam N, Nandi S, Zhivagui M, Duong J, Yang T, Herdman S, Corr M, Webster NJG, Raz E, Alexandrov LB, Bertin S.   +17 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Breast cancers arising in high mammographic density tissue harbor tumor-promoting immune profiles. [PDF]

NPJ Breast Cancer
Cheasley D, Ruppert M, Devereux L, Jayawardana MW, Zhao Q, Nickson C, Pereira M, Byrne DJ, Fox SB, Campbell IG, Britt KL.   +10 more
europepmc   +1 more source

Capturing the mutational landscape of the beta-lactamase TEM-1

Proceedings of the National Academy of Sciences of the United States of America, 2013
H. Jacquier, A. Birgy, Hervé Le Nagard, Y. Mechulam, E. Schmitt, Jérémy Glodt, Béatrice Berçot, E. Petit, J. Poulain, G. Barnaud, Pierre-Alexis Gros, O. Tenaillon   +11 more
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants. [PDF]

J Virol
Dadonaite B, Harari S, Larsen BB, Kampman L, Harteloo A, Elias-Warren A, Chu HY, Bloom JD.   +7 more
europepmc   +1 more source