Results 291 to 300 of about 14,999,742 (341)

Single-cell analysis of the somatic mutational landscape in human chondrocytes during aging and in osteoarthritis. [PDF]

Nat Aging
Ren P, Zheng C, Pang Y, Qiang Y, Sun S, Wang Q, Xu W, Lee M, Lu Z, Zhou M, He J, Liu N, Maslov AY, Dong X, Zhang C, Gao J, Vijg J.   +16 more
europepmc   +1 more source

Whole-genome landscapes of 1,364 breast cancers. [PDF]

Nature
Kim R, Yu J, Lim J, Oh BB, Nam SJ, Kim SW, Lee JE, Chae BJ, Kim JY, Park GE, Kang BJ, Paik PS, Bae SY, Yoon CI, Lee YJ, Kim D, Shin K, Lee JE, Kang J, Lee A, Connolly-Strong E, Lee S, Lee BR, Lee Y, Yi KJ, Kwon YO, Chun IH, Park J, Kim J, Choi C, Shin JY, Lee H, Kim M, Park H, Jeong I, Yi B, Lee WC, Lee JS, Park WC, Kim SH, Choi YL, Lee J, Ju YS, Park YH.   +43 more
europepmc   +1 more source

Generating Hybrid Proteins with the MSA-Transformer

Tule S, Davis S, Koludarov I, Mora A, Bodén M.   +4 more
europepmc   +1 more source

ProteoCast: a web server to predict, validate, and interpret missense variant effects

Abakarova M, Freiberger MI, Liehrmann A, Rera M, Laine E.   +4 more
europepmc   +1 more source

Landscape of parental postzygotic mutations in >11,000 rare disease trios

Garcia-Salinas OI, Sanghvi R, Sayer JA, Benach MTI, Pham MH, Scally A, Martin HC, Rahbari R.   +7 more
europepmc   +1 more source

Germline haploinsufficiency for the base excision repair gene MUTYH causes mutational signature SBS18 in multiple tumour types, specifically leading to an increased risk of colorectal cancer

Sherwood K, Fernandez-Tajes J, Gül G, Thorn S, Ward JC, Wilson JF, Palles C, Bishop DT, Houlston RS, Dunlop MG, Tomlinson IP.   +10 more
europepmc   +1 more source

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HERMES: Holographic Equivariant neuRal network model for Mutational Effect and Stability prediction

bioRxiv
Accurately predicting how amino acid substitutions alter protein function is a central challenge in biology, with applications from interpreting disease variants to engineering vaccines and therapeutic proteins.
Gian Marco Visani, Michael N. Pun, William Galvin, Eric Daniel, Kevin Borisiak, Utheri Wagura, Armita Nourmohammad   +6 more
semanticscholar   +1 more source

Multi-level Interaction Modeling for Protein Mutational Effect Prediction

arXiv.org
Protein-protein interactions are central mediators in many biological processes. Accurately predicting the effects of mutations on interactions is crucial for guiding the modulation of these interactions, thereby playing a significant role in therapeutic
Yuanle Mo, Xin Hong, Bowen Gao, Yinjun Jia, Yanyan Lan   +4 more
semanticscholar   +1 more source

MUTATIONAL EFFECTS ON PROTEIN STABILITY

Annual Review of Biochemistry, 1989
PERS PECT IVES AND S UMMAR y 765 THE PROB LEM 767 THERMODYNAM ICS OF AM INO AC ID S UBST IT UTIONS 770 GENE TIC S TUD IES O F PRO TEIN S TAB ILITy 774 COO PERA TIVITY 777 S TR UCT URA L ST UD IES OF PROTE IN VAR IAN TS 777 FORCES THAT STAB ILIZE PROTE INS 779 Effects on Conformational Entropy 779 The Hydrophobic Eff ect .. . . . . . .
openaire   +2 more sources

Mutational analysis of OsPLDα1 reveals its involvement in phytic acid biosynthesis in rice grains.

Journal of Agricultural and Food Chemistry, 2019
Phospholipids and phytic acid are important phosphorus (P) containing compounds in rice grains. Phytic acid is considered as a major anti-nutrient, because the negatively charged phytic acid chelates cations, including essential micro-nutrients and ...
M. S. S. Khan, Rasbin Basnet, S. A. Islam, Q. Shu   +3 more
semanticscholar   +1 more source