Warmer temperatures enhance beneficial mutation effects [PDF]
Journal of Evolutionary Biology, 2020 Abstract Temperature determines the rates of all biochemical and biophysical processes, and is also believed to be a key driver of macroevolutionary patterns. It is suggested that physiological constraints at low temperatures may diminish the fitness advantages of otherwise beneficial mutations; by contrast ...
Xiao‐Lin Chu +3 more
openaire +2 more sources
Recombination and mutational robustness in neutral fitness landscapes.
PLoS Computational Biology, 2019 Mutational robustness quantifies the effect of random mutations on fitness. When mutational robustness is high, most mutations do not change fitness or have only a minor effect on it.
Alexander Klug +2 more
doaj +1 more source
The Impact of Selection at the Amino Acid Level on the Usage of Synonymous Codons
G3: Genes, Genomes, Genetics, 2017 There are two main forces that affect usage of synonymous codons: directional mutational pressure and selection. The effectiveness of protein translation is usually considered as the main selectional factor.
Paweł Błażej +3 more
doaj +1 more source
Fluctuating environments select for short-term phenotypic variation leading to long-term exploration. [PDF]
PLoS Computational Biology, 2019 Genetic spaces are often described in terms of fitness landscapes or genotype-to-phenotype maps, where each genetic sequence is associated with phenotypic properties and linked to other genotypes that are a single mutational step away.
Rosangela Canino-Koning +2 more
doaj +1 more source
Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report
Frontiers in Immunology, 2021 BackgroundVaginal adenocarcinomas (VAC) are most often reported after intrauterine exposition to diethylstilbestrol (DES). Rarely, VACs are reported as a malignant transformation of vaginal adenosis or endometriosis, in the context of chromosomal ...
Eva Katharina Egger +7 more
doaj +1 more source
Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. [PDF]
, 2019 HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions.
Fernandes, Jason D +4 more
core +3 more sources
In Vivo Mutagenic Effect of Very Low Dose Radiation
Dose-Response, 2006 Almost all of our knowledge about the mutational effect of radiation has come from high dose studies which are generally not relevant to public exposure.
Pamela J. Sykes +6 more
doaj +1 more source
The evolution of heterogeneities altered by mutational robustness, gene expression noise and bottlenecks in gene regulatory networks. [PDF]
PLoS ONE, 2014 Intra-population heterogeneity is commonly observed in natural and cellular populations and has profound influence on their evolution. For example, intra-tumor heterogeneity is prevalent in most tumor types and can result in the failure of tumor therapy.
Zhihua Zhang
doaj +1 more source
New era of cystic fibrosis: full mutational analysis and personalized therapy [PDF]
, 2017 Despite its apparently simple genetics, cystic fibrosis (CF) is a rather complex genetic disease. A lot of variability in the steps of the path from the cystic fibrosis transmembrane conductance regulator (CFTR ) gene to the clinical manifestations ...
Lucarelli, Marco
core +1 more source
Zero‐shot mutation effect prediction on protein stability and function using RoseTTAFold
Protein Science, 2023 Predicting the effects of mutations on protein function and stability is an outstanding challenge. Here, we assess the performance of a variant of RoseTTAFold jointly trained for sequence and structure recovery, RFjoint, for mutation effect prediction ...
Sanaa Mansoor +4 more
semanticscholar +1 more source