Results 51 to 60 of about 14,999,742 (341)

Evolution of gene regulatory networks by fluctuating selection and intrinsic constraints. [PDF]

PLoS Computational Biology, 2010
Various characteristics of complex gene regulatory networks (GRNs) have been discovered during the last decade, e.g., redundancy, exponential indegree distributions, scale-free outdegree distributions, mutational robustness, and evolvability.
Masaki E Tsuda, Masakado Kawata
doaj   +1 more source

Canalization of the evolutionary trajectory of the human influenza virus [PDF]

, 2011
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like ...
A Kucharski, A Monto, A Park, A Rambaut, Andrew Rambaut, B Adams, B Finkelman, C Viboud, CA Russell, D Weinreich, DJ Smith, E Goldstein, E O'Dea, E Volz, F Carrat, F Tria, G Chowell, G Hirst, IG Barr, J Gog, J Lin, J O'Brien, J Truscott, J Voeten, K Koelle, K Koelle, K Koelle, K Koelle, M Recker, Mercedes Pascual, MI Nelson, NM Ferguson, R Bush, S Bhatt, S Gould, S Kryazhimskiy, S Park, T Bedford, T Bedford, Trevor Bedford, V Gupta, WM Fitch, YI Wolf, Z Yang   +43 more
core   +5 more sources

Idiosyncratic epistasis creates universals in mutational effects and evolutionary trajectories

Nature Ecology & Evolution, 2020
Patterns of epistasis and shapes of fitness landscapes are of wide interest because of their bearings on a number of evolutionary theories. The common phenomena of slowing fitness increases during adaptations and diminishing returns from beneficial ...
Daniel M. Lyons, Zhengting Zou, Haiqing Xu, Jianzhi Zhang   +3 more
semanticscholar   +1 more source

Effective fault localization via mutation analysis

Proceedings of the 29th Annual ACM Symposium on Applied Computing, 2014
When programs fail, developers face the problem of identifying the code fragments responsible for this failure. To this end, fault localization techniques try to identify suspicious program places (program statements) by observing the spectrum of the failing and passing test executions.
Papadakis, Mike, Le Traon, Yves
openaire   +2 more sources

Safe mutation with algebraic effects [PDF]

Proceedings of the 14th ACM SIGPLAN International Symposium on Haskell, 2021
It can be difficult to write safe concurrent programs which use shared mutable state. Subtle mistakes can lead to data races that manifest as unexpected program behaviour. The prevailing approaches to solving this dilemma are to either eschew mutable state altogether, or design bespoke languages that prevent data races by design.
Hashan Punchihewa, Nicolas Wu
openaire   +2 more sources

mutscan—a flexible R package for efficient end-to-end analysis of multiplexed assays of variant effect data

Genome Biology, 2023
Multiplexed assays of variant effect (MAVE) experimentally measure the effect of large numbers of sequence variants by selective enrichment of sequences with desirable properties followed by quantification by sequencing.
Charlotte Soneson, Alexandra M. Bendel, Guillaume Diss, Michael B. Stadler   +3 more
doaj   +1 more source

Estimating translational selection in Eukaryotic Genomes [PDF]

, 2009
Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the ...
Adams, Akashi, Akashi, Akashi, Akashi, Akashi, Akashi, Bennetzen, Birdsell, Bulmer, Bulmer, Chamary, Coghlan, Comeron, Cutter, dos Reis, Duret, Eyre-Walker, Eyre-Walker, Friedman, Harpending, Hartl, Holstege, Ikemura, Ikemura, Kanaya, Koonin, L. Wernisch, Lafay, Lander, Lowe, Lynch, M. dos Reis, Maside, Percudani, Reis, Sharp, Sharp, Sharp, Sherry, The C. elegans Sequencing Consortium, Urrutia, Wang, Wright   +43 more
core   +2 more sources

Islet-intrinsic effects of CFTR mutation [PDF]

Diabetologia, 2016
Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the pancreas as a whole, emerging evidence may implicate a role for cystic fibrosis transmembrane ...
Fiona N. Manderson Koivula, Neville H. McClenaghan, Alan G. S. Harper, Catriona Kelly   +3 more
openaire   +2 more sources

The Effect of Recombination on the Neutral Evolution of Genetic Robustness

, 2008
Conventional population genetics considers the evolution of a limited number of genotypes corresponding to phenotypes with different fitness. As model phenotypes, in particular RNA secondary structure, have become computationally tractable, however, it ...
Albert, Azevedo, Borenstein, Bornberg-Bauer, Ciliberti, de Visser, Gergely J. Szöllősi, Griffiths-Jones, Hofacker, Huynen, Imre Derényi, Kacser, Kimua, van Nimwegen, Wagner, Wilke, Xia, Zauner   +17 more
core   +1 more source

The mutation effect reaction norm (Mu-RN) highlights environmentally dependent mutation effects and epistatic interactions [PDF]

Evolution, 2021
AbstractSince the modern synthesis, the fitness effects of mutations and epistasis have been central yet provocative concepts in evolutionary and population genetics. Studies of how the interactions between parcels of genetic information can change as a function of environmental context have added a layer of complexity to these discussions.
openaire   +2 more sources