Results 61 to 70 of about 14,999,742 (341)
MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect
Genome Biology, 2022 Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep mutational scanning experiments on proteins and massively parallel reporter assays on gene regulatory sequences. Despite their increasing popularity, a general strategy
Ammar Tareen +5 more
doaj +1 more source
Genetic draft, selective interference, and population genetics of rapid adaptation [PDF]
, 2013 To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare.
Neher, Richard A.
core +1 more source
Mutation load under additive fitness effects [PDF]
Genetics Research, 2015 SummaryUnder the traditional mutation load model based on multiplicative fitness effects, the load in a population is 1−e−U, whereUis the genomic deleterious mutation rate. Because this load becomes high under largeU, synergistic epistasis has been proposed as one possible means of reducing the load.
openaire +2 more sources
Causes and implications of codon usage bias in RNA viruses. [PDF]
PLoS ONE, 2013 Choice of synonymous codons depends on nucleotide/dinucleotide composition of the genome (termed mutational pressure) and relative abundance of tRNAs in a cell (translational pressure).
Ilya S Belalov, Alexander N Lukashev
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Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
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The fitness effects of random mutations in single-stranded DNA and RNA bacteriophages. [PDF]
PLoS Genetics, 2009 Mutational fitness effects can be measured with relatively high accuracy in viruses due to their small genome size, which facilitates full-length sequencing and genetic manipulation.
Pilar Domingo-Calap +2 more
doaj +1 more source
An evolutionary model for simple ecosystems
, 1999 In this review some simple models of asexual populations evolving on smooth landscapes are studied. The basic model is based on a cellular automaton, which is analyzed here in the spatial mean-field limit.
Bagnoli, Franco, Bezzi, Michele
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The mutational meltdown in asexual populations [PDF]
, 1993 Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of
Butcher, D. +3 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan +5 more
wiley +1 more source
Genome Medicine, 2018 Background Cancer susceptibility germline variants generally require somatic alteration of the remaining allele to drive oncogenesis and, in some cases, tumor mutational profiles.
Alexandra R. Buckley +4 more
doaj +1 more source