Results 81 to 90 of about 14,999,742 (341)
Evaluating topography of mutational signatures with SigProfilerTopography
Genome BiologyThe mutations found in a cancer genome are shaped by diverse processes, each displaying a characteristic mutational signature that may be influenced by the genome’s architecture.
Burçak Otlu, Ludmil B. Alexandrov
doaj +1 more source
Frontiers in Genetics, 2017 Large cancer genome sequencing initiatives have led to the identification of cancer driver genes based on signals of positive selection in somatic mutation data.
Jimmy Van den Eynden +2 more
doaj +1 more source
Effect of Host Species on the Distribution of Mutational Fitness Effects for an RNA Virus
PLoS Genetics, 2011 Knowledge about the distribution of mutational fitness effects (DMFE) is essential for many evolutionary models. In recent years, the properties of the DMFE have been carefully described for some microorganisms.
Jasna Lalić, J. Cuevas, S. Elena
semanticscholar +1 more source
Analyzing Effects of Naturally Occurring Missense Mutations [PDF]
Computational and Mathematical Methods in Medicine, 2012 Single-point mutation in genome, for example, single-nucleotide polymorphism (SNP) or rare genetic mutation, is the change of a single nucleotide for another in the genome sequence. Some of them will produce an amino acid substitution in the corresponding protein sequence (missense mutations); others will not.
Zhang, Zhe +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Towards mechanistic models of mutational effects: Deep learning on Alzheimer’s Aβ peptide
Computational and Structural Biotechnology Journal, 2023 Deep Mutational Scanning (DMS) has enabled multiplexed measurement of mutational effects on protein properties, including kinematics and self-organization, with unprecedented resolution.
Bo Wang, Shahab Razavi, Eric R. Gamazon
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Somatic mutations render human exome and pathogen DNA more similar
, 2019 Immunotherapy has recently shown important clinical successes in a substantial number of oncology indications. Additionally, the tumor somatic mutation load has been shown to associate with response to these therapeutic agents, and specific mutational ...
Cristescu, Razvan +4 more
core +1 more source
Scaling laws in bacterial genomes: A side-effect of selection of mutational robustness? [PDF]
, 2010 In the past few years, numerous research projects have focused on identifying and understanding scaling properties in the gene content of prokaryote genomes and the intricacy of their regulation networks.
Adami +37 more
core +4 more sources
Accurate Mutation Effect Prediction using RoseTTAFold
bioRxiv, 2022 Predicting the effects of mutations on protein function is an outstanding challenge. Here we assess the performance of the deep learning based RoseTTAFold structure prediction and design method for unsupervised mutation effect prediction.
Sanaa Mansoor +4 more
semanticscholar +1 more source
Effect of Mutation Order on Myeloproliferative Neoplasms [PDF]
New England Journal of Medicine, 2015 Cancers result from the accumulation of somatic mutations, and their properties are thought to reflect the sum of these mutations. However, little is known about the effect of the order in which mutations are acquired.We determined mutation order in patients with myeloproliferative neoplasms by genotyping hematopoietic colonies or by means of next ...
Ortmann, Christina A. +20 more
openaire +4 more sources