Results 141 to 150 of about 18,996,847 (344)

Mutational signature distribution varies with DNA replication timing and strand asymmetry

Genome Biology, 2018
Background DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures—each representing a mutagenic process—derived from 3056 patients ...
Marketa Tomkova, Jakub Tomek, Skirmantas Kriaucionis, Benjamin Schuster-Böckler   +3 more
doaj   +1 more source

Exact Solution of an Evolutionary Model without Ageing

, 1999
We introduce an age-structured asexual population model containing all the relevant features of evolutionary ageing theories. Beneficial as well as deleterious mutations, heredity and arbitrary fecundity are present and managed by natural selection.
A. F. R. de Toledo Piza, B. Charlesworth, B. Gompertz, C. E. Finch, C. M. Sorensen, D. Stauffer, G. A. Parker, H. E. Huntley, L. Partridge, M. Heumann, M. Lynch, M. R. Rose, M. Ya. Azbel, Nazareno G. F. de Medeiros, P. B. Medawar, P. H. Leslie, R. M. C. de Almeida, R. R. Reddel, Roberto N. Onody, S. Moss de Oliveira, S. Moss de Oliveira, S. Vollmar, T. J. P. Penna, T. S. Ray   +23 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A Dirichlet-multinomial mixed model for determining differential abundance of mutational signatures

BMC Bioinformatics
Background Mutational processes of diverse origin leave their imprints in the genome during tumour evolution. These imprints are called mutational signatures and they have been characterised for point mutations, structural variants and copy number ...
Lena Morrill Gavarró, Dominique-Laurent Couturier, Florian Markowetz   +2 more
doaj   +1 more source

A practical guide for mutational signature analysis in hematological malignancies

Nature Communications, 2019
Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the generation
Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S. Puente, Herve Avet-Loiseau, Peter J. Campbell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli   +14 more
doaj   +1 more source

Fundamental Properties of the Evolution of Mutational Robustness [PDF]

, 2015
Evolution on neutral networks of genotypes has been found in models to concentrate on genotypes with high mutational robustness, to a degree determined by the topology of the network.
Altenberg, Lee
core  

Data from Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers

, 2023
Jintao Guo, Ying Zhou, Chaoqun Xu, Qinwei Chen, Zsófia Sztupinszki, Judit Börcsök, Canqiang Xu, Feng Ye, Weiwei Tang, Jiapeng Kang, Lu Yang, Jiaxin Zhong, Taoling Zhong, Tianhui Hu, Rongshan Yu, Zoltán Szállási, Xianming Deng, Qiyuan Li   +17 more
openalex   +1 more source

Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes

Nature Communications, 2017
Heterozygous mutations within homozygous sequences descended from a recent common ancestor offer a way to ascertain de novo mutations across multiple generations.
Vagheesh M. Narasimhan, R. Rahbari, A. Scally, A. Wuster, D. Mason, Yali Xue, John Wright, R. Trembath, E. Maher, D. V. van Heel, A. Auton, M. Hurles, C. Tyler-Smith, R. Durbin   +13 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source