Results 241 to 250 of about 18,996,847 (344)

A Sticky Multinomial Mixture Model of Strand-Coordinated Mutational Processes in Cancer. [PDF]

iScience, 2020
Sason I, Wojtowicz D, Robinson W, Leiserson MDM, Przytycka TM, Sharan R.   +5 more
europepmc   +1 more source

Disease-associated Mutations in the Prion Protein Impair Laminin-induced Process Outgrowth and Survival [PDF]

, 2012
Cleiton F. Machado, Flávio H. Beraldo, Tiago G. Santos, Dominique Bourgeon, Michele Christine Landemberger, Martín Roffé, Vilma R. Martins   +6 more
openalex   +1 more source

Clock-like mutational processes in human somatic cells

Nature Genetics, 2015
Ludmil B. Alexandrov, P. Jones, D. Wedge, J. Sale, P. Campbell, S. Nik-Zainal, M. Stratton   +6 more
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens [PDF]

EBioMedicine, 2017
Wei Zhu, Song Wu, Yusuf A. Hannun
openaire   +3 more sources

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Author Correction: The effects of mutational processes and selection on driver mutations across cancer types. [PDF]

Nat Commun, 2020
Temko D, Tomlinson IPM, Severini S, Schuster-Böckler B, Graham TA.   +4 more
europepmc   +1 more source

Genetic analysis of morphogenetic processes in Paramecium: I. A mutation affecting trichocyst formation and nuclear division [PDF]

, 1976
Françoise Ruiz, André Adoutte, Michèle Rossignol, Janine Beisson   +3 more
openalex   +1 more source