Results 21 to 30 of about 18,512,812 (309)

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors. [PDF]

Cell Rep, 2023
Disruption of antigen presentation via loss of MHC expression is a strategy whereby cancer cells escape immune surveillance and develop resistance to immunotherapy.
Mumphrey MB, Hosseini N, Parolia A, Geng J, Zou W, Raghavan M, Chinnaiyan A, Cieslik M.   +7 more
europepmc   +2 more sources

Single-cell genomic variation induced by mutational processes in cancer. [PDF]

Nature, 2022
How cell-to-cell copy number alterations that underpin genomic instability1 in human cancers drive genomic and phenotypic variation, and consequently the evolution of cancer2, remains understudied.
Funnell T, O'Flanagan CH, Williams MJ, McPherson A, McKinney S, Kabeer F, Lee H, Salehi S, Vázquez-García I, Shi H, Leventhal E, Masud T, Eirew P, Yap D, Zhang AW, Lim JLP, Wang B, Brimhall J, Biele J, Ting J, Au V, Van Vliet M, Liu YF, Beatty S, Lai D, Pham J, Grewal D, Abrams D, Havasov E, Leung S, Bojilova V, Moore RA, Rusk N, Uhlitz F, Ceglia N, Weiner AC, Zaikova E, Douglas JM, Zamarin D, Weigelt B, Kim SH, Da Cruz Paula A, Reis-Filho JS, Martin SD, Li Y, Xu H, de Algara TR, Lee SR, Llanos VC, Huntsman DG, McAlpine JN, IMAXT Consortium, Shah SP, Aparicio S.   +53 more
europepmc   +2 more sources

Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia. [PDF]

Mol Cell Oncol, 2016
Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes-2 types of activation induced-cytidine deaminase (AID) signatures and an aging
Kasar S, Brown JR.
europepmc   +7 more sources

A phylogenetic approach to study the evolution of somatic mutational processes in cancer. [PDF]

Commun Biol, 2022
Cancer cell genomes change continuously due to mutations, and mutational processes change over time in patients, leaving dynamic signatures in the accumulated genomic variation in tumors. Many computational methods detect the relative activities of known
Miura S, Vu T, Choi J, Townsend JP, Karim S, Kumar S.   +5 more
europepmc   +2 more sources

Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes. [PDF]

Mol Biol Evol, 2022
Mutational processes in tumors create distinctive patterns of mutations, composed of neutral “passenger” mutations and oncogenic drivers that have quantifiable effects on the proliferation and survival of cancer cell lineages.
Cannataro VL, Mandell JD, Townsend JP.
europepmc   +2 more sources

A comprehensive comparison of tools for fitting mutational signatures [PDF]

Nature Communications, 2023
Mutational signatures connect characteristic mutational patterns in the genome with biological or chemical processes that take place in cancers. Analysis of mutational signatures can help elucidate tumor evolution, prognosis, and therapeutic strategies ...
Matúš Medo, Charlotte K. Y. Ng, Michaela Medová   +2 more
doaj   +2 more sources

Population sequencing data reveal a compendium of mutational processes in the human germ line. [PDF]

Science, 2021
Gauging the spectrum of human mutations It has become increasing clear that mutation affects phenotypic variation and disease risk across humans. However, there are many different types of mutation. Seplyarskiy et al.
Seplyarskiy VB, Soldatov RA, Koch E, McGinty RJ, Goldmann JM, Hernandez RD, Barnes K, Correa A, Burchard EG, Ellinor PT, McGarvey ST, Mitchell BD, Vasan RS, Redline S, Silverman E, Weiss ST, Arnett DK, Blangero J, Boerwinkle E, He J, Montgomery C, Rao DC, Rotter JI, Taylor KD, Brody JA, Chen YI, de las Fuentes L, Hwu CM, Rich SS, Manichaikul AW, Mychaleckyj JC, Palmer ND, Smith JA, Kardia SLR, Peyser PA, Bielak LF, O'Connor TD, Emery LS, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Population Genetics Working Group, Gilissen C, Wong WSW, Kharchenko PV, Sunyaev S.   +43 more
europepmc   +2 more sources

THE PROCESS OF SPONTANEOUS EXTRANUCLEAR MUTATION IN YEAST [PDF]

Genetics, 1958
A. P. James, Peter E Spencer
openalex   +4 more sources

Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes. [PDF]

PLoS Genet, 2021
Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures of single base substitution (SBS) have been extensively studied in different types of cancer ...
Wang S, Li H, Song M, Tao Z, Wu T, He Z, Zhao X, Wu K, Liu XS.   +8 more
europepmc   +2 more sources

Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers. [PDF]

Cancer Res, 2021
The genetic determinants of the somatic mutational processes in cancer elucidate the biology underlying somatic selection and evolution of cancers and demonstrate complementary predictive power across cancer types.
Guo J, Zhou Y, Xu C, Chen Q, Sztupinszki Z, Börcsök J, Xu C, Ye F, Tang W, Kang J, Yang L, Zhong J, Zhong T, Hu T, Yu R, Szallasi Z, Deng X, Li Q.   +17 more
europepmc   +2 more sources