Results 31 to 40 of about 18,512,812 (309)
Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours [PDF]
Nature Communications, 2022 Vinayak Bhandari +4 more
doaj +2 more sources
Hotspot propensity across mutational processes. [PDF]
Mol Syst Biol, 2022 AbstractThe sparsity of mutations observed across tumours hinders our ability to study mutation rate variability at nucleotide resolution. To circumvent this, here we investigated the propensity of mutational processes to form mutational hotspots as a readout of their mutation rate variability at single base resolution.
Arnedo-Pac C +3 more
europepmc +4 more sources
Imitation processes with small mutations [PDF]
SSRN Electronic Journal, 2005 Abstract This note characterizes the impact of adding rare stochastic mutations to an “imitation dynamic,” meaning a process with the properties that absent strategies remain absent, and non-homogeneous states are transient. The resulting system will spend almost all of its time at the absorbing states of the no-mutation process. The work of Freidlin
Drew Fudenberg, Lorens A. Imhof
openalex +6 more sources
Mutational processes of simple-sequence repeat loci in human populations. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1994 Mutational processes of simple sequence repeats (SSRs) in complex genomes are poorly understood. We examined these processes by introducing a two-phase mutation model.
Anna Di Rienzo +5 more
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A contact process with mutations on a tree
Stochastic Processes and their Applications, 2007 Consider the following stochastic model for immune response. Each pathogen gives birth to a new pathogen at rate $ $. When a new pathogen is born, it has the same type as its parent with probability $1 - r$. With probability $r$, a mutation occurs, and the new pathogen has a different type from all previously observed pathogens.
Thomas M. Liggett +2 more
openalex +4 more sources
Identification of multiplicatively acting modulatory mutational signatures in cancer
BMC Bioinformatics, 2022 Background A deep understanding of carcinogenesis at the DNA level underpins many advances in cancer prevention and treatment. Mutational signatures provide a breakthrough conceptualisation, as well as an analysis framework, that can be used to build ...
Dovydas Kičiatovas +7 more
doaj +1 more source
Telomere-driven mutational processes in yeast [PDF]
Current Opinion in Genetics & Development, 2020 Telomeres are part of the system that guards genome integrity in eukaryotes, protecting linear chromosomes from fusions and degradations. The protective functions of telomeres are put at risk in physiological situations where telomeres shorten and trigger replicative senescence.
Henninger, Erin, Teixeira, Maria Teresa
openaire +4 more sources
Cancer Research, 2021 Many mutational processes associate with early or late replication timing regions independently of chromatin accessibility, enabling development of a focused identification approach to improve mutational signature detection.
Adar Yaacov +8 more
semanticscholar +1 more source
Characterization of SARS-CoV-2 Mutational Signatures from 1.5+ Million Raw Sequencing Samples
Viruses, 2022 We present a large-scale analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) substitutions, considering 1,585,456 high-quality raw sequencing samples, aimed at investigating the existence and quantifying the effect of mutational ...
Andrea Aroldi +8 more
doaj +1 more source
Birth and Death Processes with Neutral Mutations [PDF]
International Journal of Stochastic Analysis, 2012 We review recent results of ours concerning branching processes with general lifetimes and neutral mutations, under the infinitely many alleles model, where mutations can occur either at the birth of particles or at a constant rate during their lives. In both models, we study the allelic partition of the population at time t.
Champagnat, Nicolas +2 more
openaire +6 more sources