Results 41 to 50 of about 18,996,847 (344)
Mutational processes contributing to the development of multiple myeloma. [PDF]
Blood Cancer J, 2019 To gain insight into multiple myeloma (MM) tumorigenesis, we analyzed the mutational signatures in 874 whole-exome and 850 whole-genome data from the CoMMpass Study.
Hoang PH +4 more
europepmc +2 more sources
Copy number signatures and mutational processes in ovarian carcinoma. [PDF]
Nat Genet, 2018 The genomic complexity of profound copy number aberrations has prevented effective molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy number signatures from shallow whole-genome sequencing of 117 high-grade ...
Macintyre G +38 more
europepmc +2 more sources
Early divergence of mutational processes in human fetal tissues. [PDF]
Sci Adv, 2019 Different mutational processes are active in the fetal intestine than in the fetal liver. A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability.
Kuijk E +7 more
europepmc +2 more sources
Spreading processes with mutations over multilayer networks [PDF]
Proceedings of the National Academy of Sciences, 2023 A key scientific challenge during the outbreak of novel infectious diseases is to predict how the course of the epidemic changes under countermeasures that limit interaction in the population. Most epidemiological models do not consider the role of mutations and heterogeneity in the type of contact events. However, pathogens have the capacity to mutate
Mansi Sood +6 more
openalex +4 more sources
The effects of mutational processes and selection on driver mutations across cancer types. [PDF]
Nat Commun, 2018 Epidemiological evidence has long associated environmental mutagens with increased cancer risk. However, links between specific mutation-causing processes and the acquisition of individual driver mutations have remained obscure.
Temko D +4 more
europepmc +2 more sources
Computational tools to detect signatures of mutational processes in DNA from tumours: A review and empirical comparison of performance. [PDF]
PLoS One, 2019 Mutational signatures refer to patterns in the occurrence of somatic mutations that reflect underlying mutational processes. To date, after the analysis of tens of thousands of genomes and exomes from about 40 different cancers types, 30 mutational ...
Omichessan H, Severi G, Perduca V.
europepmc +2 more sources
Cell Genomics, 2022 Summary: Mouse substrains are an invaluable model for understanding disease. We compared C57BL/6J, which is the most commonly used inbred mouse strain, with eight C57BL/6 and five C57BL/10 closely related inbred substrains.
Milad Mortazavi +10 more
doaj +1 more source
Mutational topography reflects clinical neuroblastoma heterogeneity
Cell Genomics, 2023 Summary: Neuroblastoma is a pediatric solid tumor characterized by strong clinical heterogeneity. Although clinical risk-defining genomic alterations exist in neuroblastomas, the mutational processes involved in their generation remain largely unclear ...
Elias Rodriguez-Fos +17 more
doaj +1 more source
Genetic correlations in mutation processes [PDF]
Physical Review E, 1999 We study the role of phylogenetic trees on correlations in mutation processes. Generally, correlations decay exponentially with the generation number. We find that two distinct regimes of behavior exist. For mutation rates smaller than a critical rate, the underlying tree morphology is almost irrelevant, while mutation rates higher than this critical ...
Ben-Naim, E., Lapedes, A. S.
openaire +3 more sources
Imitation Processes with Small Mutations [PDF]
SSRN Electronic Journal, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fudenberg, Drew, Imhof, Lorens
openaire +3 more sources