Results 51 to 60 of about 18,512,812 (309)

Early divergence of mutational processes in human fetal tissues. [PDF]

Sci Adv, 2019
Different mutational processes are active in the fetal intestine than in the fetal liver. A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability.
Kuijk E, Blokzijl F, Jager M, Besselink N, Boymans S, Chuva de Sousa Lopes SM, van Boxtel R, Cuppen E.   +7 more
europepmc   +2 more sources

SNPs, short tandem repeats, and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains

Cell Genomics, 2022
Summary: Mouse substrains are an invaluable model for understanding disease. We compared C57BL/6J, which is the most commonly used inbred mouse strain, with eight C57BL/6 and five C57BL/10 closely related inbred substrains.
Milad Mortazavi, Yangsu Ren, Shubham Saini, Danny Antaki, Celine L. St. Pierre, April Williams, Abhishek Sohni, Miles F. Wilkinson, Melissa Gymrek, Jonathan Sebat, Abraham A. Palmer   +10 more
doaj  

A data-driven approach for constructing mutation categories for mutational signature analysis.

PLoS Computational Biology, 2021
Mutational processes shape the genomes of cancer patients and their understanding has important applications in diagnosis and treatment. Current modeling of mutational processes by identifying their characteristic signatures views each base substitution ...
Gal Gilad, Mark D M Leiserson, Roded Sharan   +2 more
doaj   +1 more source

deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Genome Biology, 2016
Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts.
R. Rosenthal, N. Mcgranahan, Javier Herrero, B. Taylor, C. Swanton   +4 more
semanticscholar   +1 more source

Mutational spectra are associated with bacterial niche

Nature Communications, 2023
As observed in cancers, individual mutagens and defects in DNA repair create distinctive mutational signatures that combine to form context-specific spectra within cells.
Christopher Ruis, Aaron Weimann, Gerry Tonkin-Hill, Arun Prasad Pandurangan, Marta Matuszewska, Gemma G. R. Murray, Roger C. Lévesque, Tom L. Blundell, R. Andres Floto, Julian Parkhill   +9 more
doaj   +1 more source

Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population

BMC Genomics, 2018
Background Esophageal squamous cell carcinomas (ESCC) is the fourth most lethal cancer in China. Previous studies reveal several highly conserved mutational processes in ESCC.
Jintao Guo, Jiankun Huang, Ying Zhou, Yulin Zhou, Liying Yu, Huili Li, Lingyun Hou, Liuwei Zhu, Dandan Ge, Yuanyuan Zeng, Bayasi Guleng, Qiyuan Li   +11 more
doaj   +1 more source

A practical framework RNMF for exploring the association between mutational signatures and genes using gene cumulative contribution abundance

Cancer Medicine, 2022
Background Mutational signatures are somatic mutation patterns enriching operational mutational processes, which can provide abundant information about the mechanism of cancer.
Zhenzhang Li, Haihua Liang, Shaoan Zhang, Wen Luo   +3 more
doaj   +1 more source

Role of epistasis on the fixation probability of a non-mutator in an adapted asexual population [PDF]

Journal of Theoretical Biology 407 (2016) 225-237, 2016
The mutation rate of a well adapted population is prone to reduction so as to have a lower mutational load. We aim to understand the role of epistatic interactions between the fitness affecting mutations in this process. Using a multitype branching process, the fixation probability of a single non-mutator emerging in a large asexual mutator population ...
arxiv   +1 more source

Influence network model uncovers relations between biological processes and mutational signatures

Genome Medicine, 2023
Background There has been a growing appreciation recently that mutagenic processes can be studied through the lenses of mutational signatures, which represent characteristic mutation patterns attributed to individual mutagens.
Bayarbaatar Amgalan, Damian Wojtowicz, Yoo-Ah Kim, Teresa M. Przytycka   +3 more
doaj   +1 more source

Accuracy of mutational signature software on correlated signatures

Scientific Reports, 2022
Mutational signatures are characteristic patterns of mutations generated by exogenous mutagens or by endogenous mutational processes. Mutational signatures are important for research into DNA damage and repair, aging, cancer biology, genetic toxicology ...
Yang Wu, Ellora Hui Zhen Chua, Alvin Wei Tian Ng, Arnoud Boot, Steven G. Rozen   +4 more
doaj   +1 more source