Results 101 to 110 of about 1,869,696 (352)

Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral cavity and oropharynx. [PDF]

, 2019
Squamous cell carcinomas of the head and neck (HNSCC) arise from mucosal keratinocytes of the upper aero-digestive tract. Despite a common cell of origin and similar driver-gene mutations which divert cell fate from differentiation to proliferation ...
Curry, Joseph, den Breems, Nicoline Y, Johnson, Jennifer M., Luginbuhl, Adam J., Martinez-Outshoorn, Ubaldo E., Nwagu, Uche, Poojan, Shiv, Richa, Tony, South, Andrew P., Zhan, Tingting   +9 more
core   +1 more source

Age-related mutational signature negatively associated with immune activity and survival outcome in triple-negative breast cancer

Oncoimmunology, 2020
Triple-negative breast cancer (TNBC) is characterized by broad genomic and transcriptional heterogeneity and results in a worse prognosis than other breast cancer types.
Hao Chen, Wei Chong, Xiaorong Yang, Y. Zhang, Shaowei Sang, Xiangchun Li, Ming Lu   +6 more
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Mutational Analysis of Uterine Cervical Cancer That Survived Multiple Rounds of Radiotherapy [PDF]

, 2019
学位記番号 ...
Endang, Nuryadi, Endang, Nuryadi, エンダング, ヌリヤディ   +2 more
core  

Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential. [PDF]

, 2020
BackgroundMetastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes.
Cadaneanu, Radu M, Freeman, Michael R, Garraway, Isla P, Grasso, Catherine S, Hodge, Jennelle, Kim, Minhyung, Knudsen, Beatrice S, Kwan, Lorna, Lewis, Michael S, Li, Xinmin, Liu, Sandy T, Miller, Eric T, Quist, Michael J, Yoon, Junhee, You, Sungyong   +14 more
core  

Modelling mutational landscapes of human cancers in vitro [PDF]

, 2014
Experimental models that recapitulate mutational landscapes of human cancers are needed to decipher the rapidly expanding data on human somatic mutations.
Alexander, J., Ardin, M., Byrnes, G., Castells, X., Hazelwood, L., Hollstein, M., Huskova, H., Marusawa, H., McKay, J., Muehlbauer, K.-R., Nedelko, T., Olivier, M., Vallée, M.P., Weninger, A., Zavadil, J.   +14 more
core   +2 more sources

High‐risk Stage III colon cancer patients identified by a novel five‐gene mutational signature are characterized by upregulation of IL‐23A and gut bacterial translocation of the tumor microenvironment

International Journal of Cancer, 2020
The heterogeneities of colorectal cancer (CRC) lead to staging inadequately of patients’ prognosis. Here, we performed a prognostic analysis based on the tumor mutational profile and explored the characteristics of the high‐risk tumors.
Weiting Ge, Hanguang Hu, W. Cai, Jinhong Xu, Wangxiong Hu, Xingyue Weng, Xin Qin, Yanqin Huang, W. Han, Yeting Hu, Jiekai Yu, Wu Zhang, Sisi Ye, Lina Qi, Pingjie Huang, Lirong Chen, K. Ding, Lidong Wang, Shu Zheng   +18 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes.

PLoS Genetics, 2021
Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures of single base substitution (SBS) have been extensively studied in different types of cancer ...
Shixiang Wang, Huimin Li, Minfang Song, Ziyu Tao, Tao Wu, Zaoke He, Xiangyu Zhao, Kai Wu, Xue-Song Liu   +8 more
doaj   +1 more source

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target [PDF]

, 2019
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy.
Abate F., Agostinelli C., Amente S., Berti E., Bertolini F., Brundu F., Cerroni L., Dellino G. I., Etebari M., Facchetti F., Falini B., Fuligni F., Indio V., Laginestra M. A., Melle F., Motta G., Orecchioni S., Paulli M., Piccioni R., Pileri A., Pileri S. A., Pimpinelli N., Rabadan R., Rossi M., Sabattini E., Sapienza M. R., Tabanelli V., Talarico G., Tarantino G., Tripodo C., Truni M.   +30 more
core   +2 more sources