Results 181 to 190 of about 84,630 (272)

A Cryoprotectant‐Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals

Advanced Materials, EarlyView.
A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee, Seongchan Kim, Jooyeun Chong, Min‐gyeong Kim, Kayeong Lim, Nan‐Ee Lee, Jahyun Koo, Jiheong Kang, Hyojin Lee   +8 more
wiley   +1 more source

Evidence for a transgenerational mutational signature from ionizing radiation exposure in humans. [PDF]

Sci Rep
Brand F, Klinkhammer H, Knaus A, Holtgrewe M, Weinhold L, Beule D, Ludwig K, Kothiyal P, Maxwell G, Noethen M, Schmid M, Sperling K, Krawitz P.   +12 more
europepmc   +1 more source

Mutational signature of extracranial meningioma metastases and their respective primary tumors. [PDF]

Acta Neuropathol Commun, 2023
Biczok A, Thorsteinsdottir J, Karschnia P, Ruf VC, Tonn JC, Herms J, Schichor C, Dorostkar MM.   +7 more
europepmc   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

A lung-specific mutational signature enables inference of viral and bacterial respiratory niche. [PDF]

Microb Genom, 2023
Ruis C, Peacock TP, Polo LM, Masone D, Alvarez MS, Hinrichs AS, Turakhia Y, Cheng Y, McBroome J, Corbett-Detig R, Parkhill J, Floto RA.   +11 more
europepmc   +1 more source

Mutation signature of aristolochic acid [PDF]

Nature Genetics, 2013
openaire   +1 more source

Label‐Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva

Advanced Materials, EarlyView.
Galvanic molecular entrapment (GME) is a label‐free method for detecting and quantifying neuroprotein conformational states. This technique enables direct surface binding and in situ hotspot generation around molecules, effectively overcoming challenges related to target localization and mismatched hotspot geometries.
Muhammad Shalahuddin Al Ja'farawy, Jun‐Yeong Yang, Chaewon Mun, Seunghun Lee, Chul Bum Cho, Yoo Hyun Um, Min‐Young Lee, Sung‐Gyu Park, Dong‐Ho Kim, Seung Ho Yang, Ho Sang Jung   +10 more
wiley   +1 more source

Mutational signatures reveal distinct subgroups [PDF]

Nature Reviews Clinical Oncology, 2016
openaire   +1 more source

NIR‐Activated Ag2S Quantum Dots for Efficient Broad‐Spectrum Antibacterial and Biofilm Disruption

Advanced Materials Interfaces, EarlyView.
This study presents a novel non‐antibiotic strategy leveraging NIR‐activated Ag2S QDs for synergistic PTT/PDT. The platform degrades the protective extracellular matrix via localized hyperthermia, facilitating deep penetration and ROS‐induced oxidative damage.
Rui Yao, Peiqing Sun, Yaxin Chen, Zhijie Lei, Li Wang, Jianglin Yu, Ying Liu, Wusimanjiang Hailipitimu, Wei Wei, Jing Zhao, Xusheng Qiu   +10 more
wiley   +1 more source

Whole-Exome Sequencing, Mutational Signature Analysis, and Outcome in Multiple Myeloma-A Pilot Study. [PDF]

Int J Mol Sci
Oelschläger L, Künstner A, Frey F, Leitner T, Leypoldt L, Reimer N, Gebauer N, Bastian L, Weisel K, Sailer VW, Röcken C, Klapper W, Konukiewitz B, Murga Penas EM, Forster M, Schub N, Ahmed HMM, Kirfel J, von Bubnoff NCC, Busch H, Khandanpour C.   +20 more
europepmc   +1 more source