APOBEC mutational signature predicts prognosis and immunotherapy response in nonsmoking patients with lung adenocarcinoma. [PDF]
Transl Lung Cancer Res, 2023 Ma J +5 more
europepmc +1 more source
Advanced Design for Weakly Coupled Resonators by Automatic Active Optimization
Advanced Materials Technologies, EarlyView.An Automatic Active Optimization (AAO) strategy integrates machine learning predictors and genetic algorithms in a closed‐loop workflow. By iteratively expanding its dataset with new discoveries, AAO overcomes the limits of conventional methods. This approach finds superior microstructural designs beyond the initial sample space. We demonstrate this on
Wei Yue +8 more
wiley +1 more source
Benchmarking 13 tools for mutational signature attribution, including a new and improved algorithm. [PDF]
Brief BioinformJiang N, Wu Y, Rozen SG.
europepmc +1 more source
Mutational signature and clonal relatedness of recurrent urothelial carcinomas with aristolochic acid. [PDF]
Front Oncol, 2022 Zhu J +9 more
europepmc +1 more source
Vat Polymerization 3D Printing for Controlled Drug Release Applications
Advanced Materials Technologies, EarlyView.ABSTRACT Vat polymerization (VP) 3D printing, a light‐based additive manufacturing technique, has emerged as a promising technique for fabricating complex drug delivery systems with high precision and spatial resolution. This layer‐by‐layer manufacturing process enables the creation of intricate geometries and customizable architectures, which are ...
Hafiz Busari +2 more
wiley +1 more source
From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures
Advanced Robotics Research, EarlyView.This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley +1 more source
Accurate and sensitive mutational signature analysis with MuSiCal. [PDF]
Nat GenetJin H +6 more
europepmc +1 more source
Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response. [PDF]
Mod Pathol, 2023 Kasago IS +14 more
europepmc +1 more source
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source