Results 191 to 200 of about 1,869,696 (352)

Referee report. For: iMutSig: a web application to identify the most similar mutational signature using shiny [version 1; peer review: 1 approved with reservations]

, 2020
Adrian Baez‐Ortega
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Mutational signature assignment heterogeneity is widespread and can be addressed by ensemble approaches. [PDF]

Brief Bioinform, 2023
Wu AJ, Perera A, Kularatnarajah L, Korsakova A, Pitt JJ.   +4 more
europepmc   +1 more source

An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target

, 2017
Satveer K. Mahil, Marika Catapano, Paola Di Meglio, Nick Dand, Helena Ahlfors, Ian Carr, Catherine Smith, Richard C. Trembath, Mark Peakman, John Wright, Francesca D. Ciccarelli, Juliet N. Barker, Francesca Capon   +12 more
openalex   +2 more sources

Identification of a six-gene signature associated with tumor mutation burden for predicting prognosis in patients with invasive breast carcinoma

, 2020
Feiran Wang, Chong Tang, Xuesong Gao, Junfei Xu   +3 more
openalex   +1 more source

Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer [PDF]

, 2018
Teresa Kaserer, Julian Blagg
openalex   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Tumor Mutation Signature Reveals the Risk Factors of Lung Adenocarcinoma with or Mutation

Cancer Control
Introduction EGFR and KRAS mutations are frequently detected in lung adenocarcinoma (LUAD). Tumor mutational signature (TMS) determination is an approach to identify somatic mutational patterns associated with pathogenic factors.
Jialiang Wang MM, Chang Guo BMed, Jiexiao Wang MM, Xiaopeng Zhang BS, Jian Qi PhD, Xiang Huang MM, Zongtao Hu MM, Hongzhi Wang MM, Bo Hong PhD   +8 more
doaj   +1 more source

Differences in mutational signature of diffuse large B-cell lymphomas according to the primary organ. [PDF]

Cancer Med, 2023
Koh HH, Yoon SE, Kim SJ, Kim WS, Cho J.
europepmc   +1 more source

A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers [PDF]

, 2017
Sjors G. J. G. In ‘t Veld, Kim Duong, Mireille H.J. Snel, Anke Witteveen, Inès J. Beumer, Leonie Delahaye, Diederik Wehkamp, René Bernards, Annuska M. Glas, Sun Tian   +9 more
openalex   +1 more source