Results 251 to 260 of about 84,630 (272)

Anthracycline-related cardiotoxicity in patients with breast cancer harboring mutational signature of homologous recombination deficiency (HRD). [PDF]

ESMO Open
Incorvaia L, Badalamenti G, Novo G, Gori S, Cortesi L, Brando C, Cinieri S, Curigliano G, Ricciardi GR, Toss A, Chiari R, Berardi R, Ballatore Z, Bono M, Bazan Russo TD, Gristina V, Galvano A, Damerino G, Blasi L, Bazan V, Russo A.   +20 more
europepmc   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Resolving mutational signatures in cancer development

Cancer Cell, 2022
In a recent Science study, an advanced mutational signature analysis was performed on an unprecedentedly large set of cancer whole-genome sequences across multiple organs. This work introduces a computational framework to identify common and rare mutational signatures and provides insights into their biological interpretation.
Tianyuan, Liu, Yuan, Lin, Chen, Wu
openaire   +2 more sources

Huge Genome Study Uncovers Mutational Signatures

Cancer Discovery, 2022
Abstract A massive survey of whole-genome–sequenced tumors has revealed dozens of new mutational signatures—many suggestive of organ-specific mutational processes, many shaped by treatment histories, and many reflective of different genetic or environmental causes of cancer.
openaire   +2 more sources

Mutation Signatures Depend on Epigenomic Contexts

Trends in Cancer, 2018
Mutation signatures - the patterns of acquired genetic changes in somatic genomes - provide critical insights into DNA repair defects and exposure to mutagenic processes during development, aging, and cancer progression. Efforts to decipher the etiology of the emerging computationally predicted mutation signatures in cancer genomes are currently ...
Neil, Coleman, Subhajyoti, De
openaire   +2 more sources

Esophageal cancer mutational signatures around the world

Nature Genetics, 2021
Mutational signatures can shed light onto mechanisms of carcinogenesis and reveal the mutagenic impact of novel and established environmental risk factors. A new study examines the mutational spectra of esophageal squamous cell cancer together with exposure information in regions of high and low incidence of the disease, and demonstrates both the ...
Marios Giannakis, Ulrike Peters
openaire   +2 more sources

Mutational signature sleuthing

Science, 2018
Cancer Individuals with the inherited skin disease recessive dystrophic epidermolysis bullosa (RDEB) are predisposed to developing aggressive squamous cell carcinomas (SCCs). Cho et al. sequenced multiple RDEB SCC tumors and found that the mutation profile in these carcinomas was most consistent with APOBEC-associated mutagenesis, unlike other types of
openaire   +1 more source

Mutational signatures and processes in hepatobiliary cancers

Nature Reviews Gastroenterology & Hepatology, 2022
The evolutionary history of hepatobiliary cancers is embedded in their genomes. By analysing their catalogue of somatic mutations and the DNA sequence context in which they occur, it is possible to infer the mechanisms underpinning tumorigenesis. These mutational signatures reflect the exogenous and endogenous origins of genetic damage as well as the ...
Ekaterina Zhuravleva, Colm J. O’Rourke, Jesper B. Andersen   +2 more
openaire   +3 more sources

PhySigs: Phylogenetic Inference of Mutational Signature Dynamics

Biocomputing 2020, 2019
Distinct mutational processes shape the genomes of the clones comprising a tumor. These processes result in distinct mutational patterns, summarized by a small number of mutational signatures. Current analyses of clone-specific exposures to mutational signatures do not fully incorporate a tumor's evolutionary context, either inferring identical ...
Sarah, Christensen, Mark D M, Leiserson, Mohammed, El-Kebir   +2 more
openaire   +2 more sources