Results 41 to 50 of about 84,630 (272)

Mutational signatures representative transcriptomic perturbations in hepatocellular carcinoma

Frontiers in Genetics, 2022
Hepatocellular carcinoma (HCC) is a primary malignancy with increasing incidence and poor prognosis. Heterogeneity originating from genomic instability is one of the critical reasons of poor outcomes.
Qiong Wu, Qiong Wu, Lingyi Wang, Stephen Kwok-Wing Tsui   +3 more
doaj   +1 more source

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer. [PDF]

, 2017
Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution.
Bivona, Trever G, Cai, Mei-Chun, Chen, Hong-Zhuan, Chen, Minjiang, Fu, Yujie, Gao, Wei-Qiang, Gu, Zhenyu, Jing, Ying, Ma, Pengfei, Shen, Ying, Wang, Mengzhao, Wu, Jie, Yan, Ying, Zhang, Shengzhe, Zhao, Xiaojing, Zhu, Liang, Zhuang, Guanglei   +16 more
core   +2 more sources

IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications [PDF]

, 2019
The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples ...
Amato, Teresa, Aversa, Sara, Bellan, Cristiana, Cencini, Emanuele, Cevenini, Gabriele, DI NAPOLI, Arianna, Di Stefano, Gioia, Giulio Carta, Alberto, Granai, Massimo, Kovalchuk, Sofya, Lazzi, Stefano, Leoncini, Lorenzo, Mancini, Virginia, Santi, Raffaella, Vergoni, Federica, Ziepert, Marita   +15 more
core   +2 more sources

The unique genomic landscape and prognostic mutational signature of Chinese clear cell renal cell carcinoma

Journal of the National Cancer Center, 2022
Background: The genomic background affects the occurrence and metastasis of cancers, including clear cell renal cell carcinoma (ccRCC). However, reports focusing on the prognostic mutational signature of Chinese ccRCC are lacking.
Wenhao Xu, Aihetaimujiang Anwaier, Wangrui Liu, Xi Tian, Jiaqi Su, Guohai Shi, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye   +8 more
doaj   +1 more source

Mutational signatures among young-onset testicular cancers [PDF]

BMC Medical Genomics, 2021
AbstractBackgroundIncidence of testicular cancer is highest among young adults and has been increasing dramatically for men born since 1945. This study aimed to elucidate the factors driving this trend by investigating differences in mutational signatures by age of onset.MethodsWe retrieved somatic variant and clinical data pertaining to 135 testicular
Nicole E. Mealey, Dylan E. O’Sullivan, Cheryl E. Peters, Daniel Y. C. Heng, Darren R. Brenner   +4 more
openaire   +4 more sources

Development and Validation of a Mutational Burden-Associated LncRNA Signature for Improving the Clinical Outcome of Hepatocellular Carcinoma

Life, 2021
Background: Long non-coding RNAs (lncRNAs) modulate numerous cellular processes, including DNA damage repair. Here, we investigated the clinical importance of lncRNAs associated with mutational burden in hepatocellular carcinoma (HCC). Methods: Prognosis-
Mingjun Xu, Ting Ma, Shanping Shi, Jingjun Xing, Yang Xi   +4 more
doaj   +1 more source

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +3 more sources

Mutational signatures in hematological malignancies [PDF]

Einstein (São Paulo)
The set of somatic mutations present in a human tumor is a record of one or more mutational processes, each of which leaves distinct "signature" of mutation types.
Felipe de Almeida Sartori, João Vitor Paes Pontes, Paulo Vidal Campregher, Thomas LaFramboise   +3 more
doaj   +2 more sources

Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma. [PDF]

, 2014
While liposarcoma is the second most common soft tissue malignant tumor, the molecular pathogenesis in this malignancy is poorly understood. Our goal was therefore to expand the understanding of molecular mechanisms that drive liposarcoma and identify ...
Borger, Darrell R, Choy, Edwin, Cote, Gregory, Duan, Zhenfeng, Fan, Kenneth C, Guo, Shang, Harmon, David, Hornicek, Francis J, Lopez-Marquez, Hector, Mankin, Henry, Nielsen, G Petur, Yang, Cao, Zhang, Changqing   +12 more
core   +2 more sources

Unveiling the interplay between mutational signatures and tumor microenvironment: a pan-cancer analysis

Frontiers in Immunology, 2023
BackgroundWhile recent studies have separately explored mutational signatures and the tumor microenvironment (TME), there is limited research on the associations of both factors in a pan-cancer context.Materials and methodsWe performed a pan-cancer ...
Li-Zhi Luo, Sheng Li, Chen Wei, Jiao Ma, Li-Mei Qian, Yan-Xing Chen, Shi-Xiang Wang, Qi Zhao   +7 more
doaj   +1 more source