Results 51 to 60 of about 1,869,696 (352)

Association of clock-like mutational signature with immune checkpoint inhibitor outcome in patients with melanoma and NSCLC

Molecular Therapy: Nucleic Acids, 2021
Immune checkpoint inhibitor (ICI) therapy has achieved remarkable clinical benefit in melanoma and non-small cell lung cancer (NSCLC). Tumor mutational signatures are the fingerprints of endogenous and exogenous factors that have acted throughout ...
Wei Chong, Zhe Wang, Liang Shang, Shengtao Jia, Jin Liu, Zhen Fang, Fengying Du, Hao Wu, Yang Liu, Yang Chen, Hao Chen   +10 more
doaj   +1 more source

Mutational Signatures in Salivary Gland Carcinomas

Cancer Diagnosis & Prognosis, 2023
Salivary gland carcinomas belong to the head and neck carcinoma super category of malignancies. They are characterized by histopathological diversity and comprise a variety of entities and subtypes. Mucoepidermoid, adenoid cystic and salivary duct carcinomas represent the most prominent malignancies. Concerning their corresponding genetic background, a
Chrysovergis, Aristeidis, Papanikolaou, Vasileios, Spyropoulou, Despoina, Roukas, Dimitrios, Asimakopoulos, Asimakis D., Papanastasiou, George, Mastronikoli, Sofianiki, Falidas, Evangelos, Papouliakos, Sotirios, Tsiambas, Evangelos, Pantos, Pavlos, Ragos, Vasileios, Peschos, Dimitrios, Mastronikolis, Nicholas, Kyrodimos, Efthymios   +14 more
openaire   +3 more sources

CoMutPlotter: a web tool for visual summary of mutations in cancer cohorts

BMC Medical Genomics, 2019
Background CoMut plot is widely used in cancer research publications as a visual summary of mutational landscapes in cancer cohorts. This summary plot can inspect gene mutation rate and sample mutation burden with their relevant clinical details, which ...
Po-Jung Huang, Hou-Hsien Lin, Chi-Ching Lee, Ling-Ya Chiu, Shao-Min Wu, Yuan-Ming Yeh, Petrus Tang, Cheng-Hsun Chiu, Ping-Chiang Lyu, Pei-Chien Tsai   +9 more
doaj   +1 more source

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis [PDF]

, 2014
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes.
Anderson, M, Bailey, P, Barbour, A, Bruxner, T, Campbell, P, Christ, A, Fink, J, Gotley, D, Grimmond, S, Harliwong, I, Hayward, N, Holmes, O, Hussey, D, Idrisoglu, S, Kazakoff, S, Krause, L, Lampe, G, Leonard, C, Loffler, K, Lord, R, Manning, S, Miller, D, Nancarrow, D, Newell, F, Nones, K, Nourbakhsh, E, Nourse, C, Patch, A, Pearson, J, Phillips, W, Quek, K, Quinn, M, Reid, L, Simpson, P, Smithers, B, Tang, Y, Waddell, N, Waddell, N, Watson, D, Wayte, N, Whiteman, D, Wilson, P, Wood, S, Xu, Q   +43 more
core   +4 more sources

CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data

Nature Communications, 2021
Systematic DNA sequencing of cancer samples has highlighted the importance of two aspects of cancer genomics: intra-tumor heterogeneity (ITH) and mutational processes.
J. Abécassis, F. Reyal, Jean-Philippe Vert   +2 more
semanticscholar   +1 more source

Mutational processes in cancer preferentially affect binding of particular transcription factors

Scientific Reports, 2021
Protein binding microarrays provide comprehensive information about the DNA binding specificities of transcription factors (TFs), and can be used to quantitatively predict the effects of DNA sequence variation on TF binding.
Mo Liu, Arnoud Boot, Alvin W. T. Ng, Raluca Gordân, Steven G. Rozen   +4 more
doaj   +1 more source

Mutational signatures representative transcriptomic perturbations in hepatocellular carcinoma

Frontiers in Genetics, 2022
Hepatocellular carcinoma (HCC) is a primary malignancy with increasing incidence and poor prognosis. Heterogeneity originating from genomic instability is one of the critical reasons of poor outcomes.
Qiong Wu, Qiong Wu, Lingyi Wang, Stephen Kwok-Wing Tsui   +3 more
doaj   +1 more source

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer. [PDF]

, 2017
Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution.
Bivona, Trever G, Cai, Mei-Chun, Chen, Hong-Zhuan, Chen, Minjiang, Fu, Yujie, Gao, Wei-Qiang, Gu, Zhenyu, Jing, Ying, Ma, Pengfei, Shen, Ying, Wang, Mengzhao, Wu, Jie, Yan, Ying, Zhang, Shengzhe, Zhao, Xiaojing, Zhu, Liang, Zhuang, Guanglei   +16 more
core   +2 more sources

Mutational signatures reveal mutual exclusivity of homologous recombination and mismatch repair deficiencies in colorectal and stomach tumors

Scientific Data, 2023
Decomposing somatic mutation spectra into mutational signatures and their corresponding etiologies provides a powerful approach for investigating the mechanism of DNA damage and repair.
Amir Farmanbar, Robert Kneller, Sanaz Firouzi   +2 more
doaj   +1 more source

The unique genomic landscape and prognostic mutational signature of Chinese clear cell renal cell carcinoma

Journal of the National Cancer Center, 2022
Background: The genomic background affects the occurrence and metastasis of cancers, including clear cell renal cell carcinoma (ccRCC). However, reports focusing on the prognostic mutational signature of Chinese ccRCC are lacking.
Wenhao Xu, Aihetaimujiang Anwaier, Wangrui Liu, Xi Tian, Jiaqi Su, Guohai Shi, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye   +8 more
doaj   +1 more source