Results 61 to 70 of about 1,869,696 (352)
Robust monomer-distribution biosignatures in evolving digital biota [PDF]
, 2011 Because organisms synthesize component molecules at rates that reflect those molecules' adaptive utility, we expect a population of biota to leave a distinctive chemical signature on their environment that is anomalous given the local (abiotic) chemistry.
Abelson P.H. +3 more
core +3 more sources
Nodal marginal zone mutational signature [PDF]
Blood, 2016 In this issue of Blood , [Spina and coworkers][1] describe the nodal marginal zone lymphoma (NMZL) mutational signature, identifying family links with other marginal zone lymphoma types (NOTCH2, KLF2) and specific mutated genes (PTPRD).[1][2] ![Figure][3] Relative frequency of the ...
openaire +2 more sources
Life, 2021 Background: Long non-coding RNAs (lncRNAs) modulate numerous cellular processes, including DNA damage repair. Here, we investigated the clinical importance of lncRNAs associated with mutational burden in hepatocellular carcinoma (HCC). Methods: Prognosis-
Mingjun Xu +4 more
doaj +1 more source
The mutational signature profile of known and suspected human carcinogens in mice
Nature Genetics, 2020 Epidemiological studies have identified many environmental agents that appear to significantly increase cancer risk in human populations. By analyzing tumor genomes from mice chronically exposed to 1 of 20 known or suspected human carcinogens, we reveal ...
L. Riva +13 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 BackgroundWhile recent studies have separately explored mutational signatures and the tumor microenvironment (TME), there is limited research on the associations of both factors in a pan-cancer context.Materials and methodsWe performed a pan-cancer ...
Li-Zhi Luo +7 more
doaj +1 more source
IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications [PDF]
, 2019 The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples ...
Amato, Teresa +15 more
core +2 more sources
Mutational signature SBS8 predominantly arises due to late replication errors in cancer
Communications Biology, 2020 Although a majority of somatic mutations in cancer are passengers, their mutational signatures provide mechanistic insights into mutagenesis and DNA repair processes.
V. Singh +4 more
semanticscholar +1 more source
Mutational signatures among young-onset testicular cancers [PDF]
BMC Medical Genomics, 2021 AbstractBackgroundIncidence of testicular cancer is highest among young adults and has been increasing dramatically for men born since 1945. This study aimed to elucidate the factors driving this trend by investigating differences in mutational signatures by age of onset.MethodsWe retrieved somatic variant and clinical data pertaining to 135 testicular
Nicole E. Mealey +4 more
openaire +4 more sources
Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma. [PDF]
, 2014 While liposarcoma is the second most common soft tissue malignant tumor, the molecular pathogenesis in this malignancy is poorly understood. Our goal was therefore to expand the understanding of molecular mechanisms that drive liposarcoma and identify ...
Borger, Darrell R +12 more
core +2 more sources
Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer
BMC Cancer, 2018 Background Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due to increased neoantigen expression.
Timothy O’Donnell +7 more
doaj +1 more source