Results 71 to 80 of about 1,869,696 (352)

Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma

Theranostics, 2020
Rationale: Dietary exposure to aristolochic acids and similar compounds (collectively, AA) is a significant risk factor for nephropathy and subsequent upper tract urothelial carcinoma (UTUC).
Huan Lu, Yuan Liang, B. Guan, Yue Shi, Y. Gong, Juan Li, W. Kong, Jin Liu, D. Fang, Li-bo Liu, Qun He, M. Shakeel, Xuesong Li, Li-qun Zhou, W. Ci   +14 more
semanticscholar   +1 more source

Impact of cancer mutational signatures on transcription factor motifs in the human genome

BMC Medical Genomics, 2019
Background Somatic mutations in cancer genomes occur through a variety of molecular mechanisms, which contribute to different mutational patterns. To summarize these, mutational signatures have been defined using a large number of cancer genomes, and ...
Calvin Wing Yiu Chan, Zuguang Gu, Matthias Bieg, Roland Eils, Carl Herrmann   +4 more
doaj   +1 more source

Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers

Cell Reports, 2022
Summary: Mutational signatures defined by single base substitution (SBS) patterns in cancer have elucidated potential mutagenic processes that contribute to malignancy.
Rachel A. DeWeerd, Eszter Németh, Ádám Póti, Nataliya Petryk, Chun-Long Chen, Olivier Hyrien, Dávid Szüts, Abby M. Green   +7 more
doaj   +1 more source

Role of ultraviolet mutational signature versus tumor mutation burden in predicting response to immunotherapy

Molecular Oncology, 2020
Hydrophobic neoantigens are more immunogenic because they are better presented by the major histocompatibility complex and better recognized by T cells. Tumor cells can evade the immune response by expressing checkpoints such as programmed death ligand 1.
Timothy V. Pham, A. Boichard, A. Goodman, P. Riviere, Huwate Yeerna, P. Tamayo, R. Kurzrock   +6 more
semanticscholar   +1 more source

The evolution of hematopoietic cells under cancer therapy

Nature Communications, 2021
The mutational effects of chemotherapies on healthy cells are unclear. Here, the authors show that the mutational signature of platinum-based drugs -but not 5-fluorouracil- is detectable in secondary acute myeloid leukemia, implying that the clonal ...
Oriol Pich, Albert Cortes-Bullich, Ferran Muiños, Marta Pratcorona, Abel Gonzalez-Perez, Nuria Lopez-Bigas   +5 more
doaj   +1 more source

MoKCa database - mutations of kinases in cancer [PDF]

, 2009
Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer therapies The MoKCa database ...
Alfarano, Altschul, Berman, Braconi Quintaje, Bruford, Burnworth, Chatr-aryamontri, Christopher J. Richardson, Clifford, Costas Mitsopoulous, Daley, Diella, Fernández, Finn, Flicek, Forbes, Frances M. G. Pearl, Gene Ontology Consortium, Greenman, Greenman, Hanahan, Hulo, Kaminker, Kaminker, Kerrien, Koorstra, Lappalainen, Laurence H. Pearl, Letunic, Manning, Marketa Zvelebil, Mishra, Ng, O'Brien, Ortutay, Pagel, Pearl, Qiong Gao, Sawyers, Sjöblom, Stark, Torkamani, UniProt Consortium, Vastrik, Velankar, Wheeler, Wood, Yeats   +47 more
core   +3 more sources

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +3 more sources

Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types

Genome Research, 2020
Mutational signatures can reveal the history of mutagenic processes that cells were exposed to before and during tumorigenesis. We expect that as-yet-undiscovered mutational processes will shed further light on mutagenesis leading to carcinogenesis. With
Arnoud Boot, A. Ng, F. Chong, Szu-Chi Ho, Willie Yu, D. Tan, N. Iyer, S. Rozen   +7 more
semanticscholar   +1 more source

Topography of mutational signatures in human cancer

Cell Reports, 2022
SUMMARYThe somatic mutations found in a cancer genome are imprinted by different mutational processes. Each process exhibits a characteristic mutational signature, which can be affected by the genome architecture. However, the interplay between mutational signatures and topographical genomic features has not been extensively explored.
Burçak Otlu, Marcos Díaz-Gay, Ian Vermes, Erik N. Bergstrom, Maria Zhivagui, Mark Barnes, Ludmil B. Alexandrov   +6 more
openaire   +3 more sources

BASCULE: bayesian inference and clustering of mutational signatures leveraging biological priors

Genome Biology
Mutational signatures provide key insights into cancer mutational processes, but the availability of signature catalogues generated by different groups using distinct methodologies underscores a need for standardization. We introduce a Bayesian framework
Elena Buscaroli, Azad Sadr, Riccardo Bergamin, Salvatore Milite, Edith Natalia Villegas Garcia, Arianna Tasciotti, Alessio Ansuini, Daniele Ramazzotti, Nicola Calonaci, Giulio Caravagna   +9 more
doaj   +1 more source