Results 141 to 150 of about 84,383 (263)

Cancer Signature Investigation:ERBB2(HER2)-Activating Mutation and Amplification-Positive Breast Carcinoma Mimicking Lung Primary [PDF]

, 2015
Jennifer Shih, Babar Bashir, Karen S. Gustafson, Mark Andrake, Roland L. Dunbrack, Lori J. Goldstein, Yanis Boumber   +6 more
openalex   +1 more source

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A. Thackaberry, Marco Colonna, Raj Rajagovindan   +8 more
wiley   +1 more source

[Von-Hippel-Lindau gene mutation types. Association of gene expression signatures in clear cell renal cell carcinoma].

, 2008
Van Duc Luu, Bettina Fischer, Adriana von Teichman, Gunther Boysen, Kirsten D. Mertz, Philip Zimmermann, Holger Moch, Peter Schraml   +7 more
openalex   +1 more source

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency [PDF]

, 2015
Michal Kováč, Claudia Blattmann, Sebastian Ribi, Jan Smida, Nikola S. Mueller, Florian Engert, Francesc Castro-Giner, Joachim Weischenfeldt, Monika Kováčová, Andreas H. Krieg, Dimosthenis Andreou, Per‐Ulf Tunn, H. R. Dürr, H. Rechl, Klaus‐Dieter Schaser, I. Melcher, Stefan Burdach, Andreas E. Kulozik, Katja Specht, Karl Heinimann, Simone Fulda, Stefan Bielack, Gernot Jundt, Ian Tomlinson, Jan O. Korbel, Michaela Nathrath, Daniel Baumhoer   +26 more
openalex   +1 more source

Universal Proteomic Signature After Exercise‐Induced Muscle Injury in Muscular Dystrophies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Several neuromuscular disorders (NMDs) are characterized by progressive muscle damage and are marked by the elevation of circulating muscle proteins from activity‐related injury. Despite a diverse array of genetic drivers, many NMDs share similar patterns of exercise intolerance and higher concentrations of muscle injury proteins ...
Mads G. Stemmerik, Benjamin Barthel, Nanna R. Andersen, Sofie V. Skriver, Alan J. Russell, John Vissing   +5 more
wiley   +1 more source

Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma [PDF]

, 2015
Rabea Wagener, Ludmil B. Alexandrov, Manuel Montesinos‐Rongen, Matthias Schlesner, Andrea Haake, Hans G. Drexler, Julia Richter, Graham R. Bignell, Ultan McDermott, Reiner Siebert   +9 more
openalex   +1 more source

Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Deep brain stimulation offers a unique opportunity to record neural activity of the basal ganglia. While much work in dystonia has focused on the globus pallidus internus, expanding research to investigate subthalamic nucleus (STN) activity in various dystonia types is critical to provide a comprehensive understanding of dystonia ...
Zhu Guan‐Yu, Yin Zi‐Xiao, Chen Ying‐Chuan, Timon Merk, Thomas Binns, Ma Ruo‐Yu, Du Ting‐Ting, Liu Yu‐Ye, Xie Hu‐Tao, Shi Lin, Yang An‐Chao, Meng Fan‐Gang, Wolf‐Julian Neumann, Andrea A. Kühn, Zhang Jian‐Guo   +14 more
wiley   +1 more source

Polymerase ζ Activity Is Linked to Replication Timing in Humans: Evidence from Mutational Signatures [PDF]

, 2015
Vladimir B. Seplyarskiy, Georgii A. Bazykin, Ruslan Soldatov   +2 more
openalex   +1 more source

Spatiotemporal Control Over Protein Release from Artificial Cells via a Light‐Activatable Protease

Advanced Biology, EarlyView.
Stimulus‐responsive protein release is essential for intercellular communication. Mimicking this functionality in artificial cells is promising to study the working principles of cellular signaling. Herein, an engineered light‐activatable protease is implemented in a coacervate‐based artificial cell platform to establish user‐defined spatiotemporal ...
Arjan Hazegh Nikroo, Wiggert J. Altenburg, Thijs W. van Veldhuisen, Luc Brunsveld, Jan C. M. van Hest   +4 more
wiley   +1 more source

Mutational Signatures in Salivary Gland Carcinomas. [PDF]

Cancer Diagn Progn, 2023
Chrysovergis A, Papanikolaou V, Spyropoulou D, Roukas D, Asimakopoulos AD, Papanastasiou G, Mastronikoli S, Falidas E, Papouliakos S, Tsiambas E, Pantos P, Ragos V, Peschos D, Mastronikolis N, Kyrodimos E.   +14 more
europepmc   +1 more source