Results 181 to 190 of about 84,383 (263)

Distinct genomic features and mutational signatures of nucleotide excision repair and mismatch repair in thymoma. [PDF]

Am J Cancer Res
Cheng PL, Wang WJ, Chuang CY, Lin CH, Huang CY, Hsiao TH, Hsu CP.   +6 more
europepmc   +1 more source

Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all' solution. [PDF]

Biochem Soc Trans, 2023
Ivanov D, Hwang T, Sitko LK, Lee S, Gartner A.   +4 more
europepmc   +1 more source

A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma [PDF]

, 2018
Xiangchun Li, Meihua Wang, Meng Yang, Hong Dai, Baifeng Zhang, W. Wang, Xianming Chu, Xin Wang, Hong Zheng, Ruifang Niu, W. Zhang, Kexin Chen   +11 more
openalex   +1 more source

Performance of Liquid Biopsy‐Based Multi‐Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE‐I)

Advanced Science, EarlyView.
Following a comparative analysis of omics‐based cancer detection models, a novel liquid biopsy‐based multi‐omics combined model is developed for the early detection of gynecological malignancies. By integrating cell‐free DNA methylation and tumor protein markers, the combined model demonstrates high specificity and sensitivity and is uniquely designed ...
Zheng Feng, Huijuan Ge, Jingshu Wang, Yanan Wang, Xiaoran Sun, Bo Yang, Siyu Cao, Chenlian Quan, Qinhao Guo, Yusheng Han, Feidie Duan, Fang liu, Jing Zhao, Guoqiang Wang, Yuzi Zhang, Shangli Cai, Xiaohua Wu, Hao Wen   +17 more
wiley   +1 more source

Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking. [PDF]

Chem Res Toxicol, 2023
Mingard C, Battey JND, Takhaveev V, Blatter K, Hürlimann V, Sierro N, Ivanov NV, Sturla SJ.   +7 more
europepmc   +1 more source

Experimental analysis of exome-scale mutational signature of glycidamide, the reactive metabolite of acrylamide [PDF]

, 2018
Maria Zhivagui, Maude Ardin, Alvin Wei Tian Ng, Mona I. Churchwell, Manuraj Pandey, Stéphanie Villar, Vincent Cahais, Alexis Robitaille, Liacine Bouaoun, Adriana Heguy, Kathryn Z. Guyton, Martha R. Stampfer, James McKay, Monica Hollstein, Magali Olivier, Steve Rozen, Frederick A. Beland, Michael Korenjak, Jiří Zavadil   +18 more
openalex   +1 more source

Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma

Advanced Science, EarlyView.
This study discovers that SIRT1, a hub gene involved in glucolipid metabolic conversion in colorectal carcinoma (CRC), stimulates CX3CL1 secretion in CRC cells by activating FOXO1. The CX3CL1‐CX3CR1 signaling promotes the differentiation of TCF7+ regulatory T cells (Tregs) into an enhanced immunosuppressive TNFRSF9+ Treg phenotype.
Ruiyang Zi, Xiang Zhao, Limei Liu, Yijie Wang, Rui Zhang, Zhiheng Bian, Haoran Jiang, Taorui Liu, Yixin Sun, Han Peng, Xuesong Wang, Fanghao Lu, Chao Zhang, Fan Zhang, Qing Qin, Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong   +18 more
wiley   +1 more source

An Expanding Universe of Mutational Signatures and Its Rapid Evolution in Single-Stranded RNA Viruses. [PDF]

Mol Biol Evol
Yang Y, Zhang X, Chen T, Wu F, Huang YS, Qu Y, Xu M, Ma L, Liu M, Zhai W.   +9 more
europepmc   +1 more source

Transcriptional and mutational signatures of the Drosophila ageing germline. [PDF]

Nat Ecol Evol, 2023
Witt E, Langer CB, Svetec N, Zhao L.
europepmc   +1 more source

CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor‐Associated Macrophages to Promote Tumor Progression

Advanced Science, EarlyView.
This study elucidates the crosstalk between tumor‐associated macrophages (TAMs) and anaplastic thyroid cancer stem cells (ATCSCs). The findings reveal that CCL20 from THP‐1‐M2 activates the IRAK‐1/NF‐κB1/2 pathway in ATCSCs, thereby enhancing CXCL5 secretion.
Qi Liu, Yan Wang, Mingyuan Song, Jiapeng Huang, Jinyuan Shi, Wei Sun, Xiaoyu Ji, Yuang Chang, Bing Ma, Ping Zhang, Yuanyuan Yan, Hao Zhang   +11 more
wiley   +1 more source