Results 191 to 200 of about 84,383 (263)

Multiomics and machine-learning identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis. [PDF]

Brain, 2023
Catanese A, Rajkumar S, Sommer D, Masrori P, Hersmus N, Van Damme P, Witzel S, Ludolph A, Ho R, Boeckers TM, Mulaw M.   +10 more
europepmc   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Diffsig: Associating Risk Factors with Mutational Signatures. [PDF]

Cancer Epidemiol Biomarkers Prev
Park JE, Smith MA, Van Alsten SC, Walens A, Wu D, Hoadley KA, Troester MA, Love MI.   +7 more
europepmc   +1 more source

Combined large cell neuroendocrine carcinoma and endometrioid carcinoma of the endometrium: a shared gene mutation signature between the two histological components

, 2016
Masayo Ariura, Rika Kasajima, Yohei Miyagi, Yumi Ishidera, Sugo Yoshinobu, Yuka Oi, Hiroyuki Hayashi, Hiroyuki Shigeta, Etsuko Miyagi   +8 more
openalex   +2 more sources

EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer [PDF]

, 2019
Michel Wassef, Armelle Luscan, Setareh Aflaki, Dina Zielinski, Pascal W.T.C. Jansen, H. Irem Baymaz, Aude Battistella, Carole Kersouani, Nicolas Servant, Margaret R. Wallace, P. Romero, Olivier Kosmider, Pierre‐Alexandre Just, Mikaël Hivelin, Sébastien Jacques, Anne Vincent‐Salomon, Michiel Vermeulen, Michel Vidaud, Éric Pasmant, Raphaël Margueron   +19 more
openalex   +1 more source

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan‐Cancer

Advanced Science, EarlyView.
This article introduces the Brim model, an interpretable multimodal fusion framework that integrates histopathology, genomics, and transcriptomics to enhance cancer prognosis prediction. Addressing real‐world data limitations, the model enables precise predictions even with incomplete molecular data.
Feng Gao, Junxiang Ding, Baowen Gai, Du Cai, Chuling Hu, Feng‐Ao Wang, Ruikun He, Junwei Liu, Yixue Li, Xiao‐Jian Wu   +9 more
wiley   +1 more source

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
wiley   +1 more source

Mutational Signatures in Colorectal Cancer: Translational Insights, Clinical Applications, and Limitations. [PDF]

Cancers (Basel)
Crisafulli G.
europepmc   +1 more source

Mutational burden and signatures in 4000 Japanese cancers provide insights into tumorigenesis and response to therapy [PDF]

, 2019
Keiichi Hatakeyama, Takeshi Nagashima, Keiichi Ohshima, Sumiko Ohnami, Shumpei Ohnami, Yuji Shimoda, Masakuni Serizawa, Koji Maruyama, Akane Naruoka, Yasuto Akiyama, Kenichi Urakami, Masatoshi Kusuhara, Tohru Mochizuki, Ken Yamaguchi   +13 more
openalex   +1 more source

A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer

Advanced Science, EarlyView.
The hierarchical organization of the eukaryotic genome is vital for nuclear function, and disruptions from genetic mutations can alter this 3D architecture. Cataloging thousands of interchromosomal translocations, structural variants, and single nucleotide polymorphisms, their impact on 3D genome organization is revealed. The scoring algorithm, 3DFunc,
Li Tang, Matthew C. Hill, Mingxing He, Junhao Chen, Zirui Wang, Patrick T. Ellinor, Min Li   +6 more
wiley   +1 more source