Results 201 to 210 of about 84,383 (263)

Comprehensive whole-genome sequencing reveals origins of mutational signatures associated with aging, mismatch repair deficiency and temozolomide chemotherapy. [PDF]

Nucleic Acids Res
Hwang T, Sitko LK, Khoirunnisa R, Navarro-Aguad F, Samuel DM, Park H, Cheon B, Mutsnaini L, Lee J, Otlu B, Takeda S, Lee S, Ivanov D, Gartner A.   +13 more
europepmc   +1 more source

Unravelling the instability of mutational signatures extraction via archetypal analysis. [PDF]

Front Genet, 2022
Pancotti C, Rollo C, Birolo G, Benevenuta S, Fariselli P, Sanavia T.   +5 more
europepmc   +1 more source

An Exon Signature to Estimate the Tumor Mutational Burden of Right-sided Colon Cancer Patients [PDF]

, 2019
Wenbing Guo, Yelin Fu, Liangliang Jin, Kai Song, Ruihan Yu, Tianhao Li, Lishuang Qi, Yunyan Gu, Wenyuan Zhao, Zheng Guo   +9 more
openalex   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Somatic mutational landscape reveals mutational signatures and significantly mutated genes of cancer immunotherapeutic outcome and sex disparities. [PDF]

Front Immunol
Li Y, Wang Q, Gao X, Zheng J, Zhang W, Ren Y, Shen W, Su W, Lu P.   +8 more
europepmc   +1 more source

Mutational signatures in upper tract urothelial carcinoma define etiologically distinct subtypes with prognostic relevance [PDF]

, 2019
Xuesong Li, Huan Lü, Bao Guan, Zhengzheng Xu, Yue Shi, Juan Li, Wenwen Kong, Jin Liu, Dong Fang, Libo Liu, Qi Shen, Yanqing Gong, Shiming He, Qun He, Liqun Zhou, Weimin Ci   +15 more
openalex   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Topography of mutational signatures in non-small cell lung cancer: emerging concepts, clinical applications, and limitations. [PDF]

Oncologist
Jayakrishnan R, Kwiatkowski DJ, Rose MG, Nassar AH.   +3 more
europepmc   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Mutational signatures of colorectal cancers according to distinct computational workflows. [PDF]

Brief Bioinform
Battuello P, Corti G, Bartolini A, Lorenzato A, Sogari A, Russo M, Di Nicolantonio F, Bardelli A, Crisafulli G.   +8 more
europepmc   +1 more source