Results 291 to 300 of about 77,245 (318)

Broad cross-T cell immunity between emerging SARS-CoV-2 serotypes waved by spike-signature mutations

Yuanyuan Guo, Jinmin Tian, Peipei Guo, Xin Wang, Bingli Shang, Junying She, Mengjie Yang, George F. Gao, Jun Liu   +8 more
openalex   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients. [PDF]

BMC Cancer
Terlouw D, Boot A, Ducarmon QR, Nooij S, Suerink M, van Leerdam ME, van Egmond D, Tops CM, Zwittink RD, Ruano D, Langers AMJ, Nielsen M, van Wezel T, Morreau H.   +13 more
europepmc   +1 more source

Adenomas from individuals with pathogenic biallelic variants in the MUTYH and NTHL1 genes demonstrate base excision repair tumour mutational signature profiles similar to colorectal cancers, expanding potential diagnostic and variant classification applications

Romy Walker, Jihoon E. Joo, Khalid Mahmood, Mark Clendenning, Julia Como, Susan Preston, Sharelle Joseland, Bernard J. Pope, Ana Beatriz Deleame Medeiros, Brenely V. Murillo, Nicholas Pachter, Kevin Sweet, Allan D. Spigelman, Alexandra Groves, Margaret Gleeson, Krzysztof Bernatowicz, Nicola Poplawski, Lesley Andrews, Emma Healey, Steven Gallinger, Robert C. Grant, Aung Ko Win, John L. Hopper, Mark A. Jenkins, Giovana Tardin Torrezan, Christophe Rosty, Finlay Macrae, Ingrid Winship, Daniel D. Buchanan, Peter Georgeson   +29 more
openalex   +1 more source

The Association between Mutational Signatures and Clinical Outcomes among Patients with Early-Onset Breast Cancer. [PDF]

Genes (Basel)
Basmadjian RB, O'Sullivan DE, Quan ML, Lupichuk S, Xu Y, Cheung WY, Brenner DR.   +6 more
europepmc   +1 more source

A Dirichlet-multinomial mixed model for detecting differential abundance of mutational signatures

́ LMG, Couturier D, Markowetz F.
europepmc   +1 more source

Joint inference of mutational signatures from indels and single-nucleotide substitutions reveals prognostic impact of homologous recombination deficiency in tumors

Supek F, Ferrer-Torres P.
europepmc   +1 more source

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Resolving mutational signatures in cancer development

Cancer Cell, 2022
In a recent Science study, an advanced mutational signature analysis was performed on an unprecedentedly large set of cancer whole-genome sequences across multiple organs. This work introduces a computational framework to identify common and rare mutational signatures and provides insights into their biological interpretation.
Tianyuan, Liu, Yuan, Lin, Chen, Wu
openaire   +2 more sources