Results 61 to 70 of about 77,245 (318)
BMC Bioinformatics, 2018 Background Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice.
Marcos Díaz-Gay +5 more
doaj +1 more source
Learning mutational signatures and their multidimensional genomic properties with TensorSignatures
Nature Communications, 2021 Currently available tools for the analysis of mutational signatures do not make use of all possible genomic properties aside from mutation patterns.
Harald Vöhringer +3 more
doaj +1 more source
Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations. [PDF]
PLoS Genetics, 2018 Driver mutations are the genetic variants responsible for oncogenesis, but how specific somatic mutational events arise in cells remains poorly understood. Mutational signatures derive from the frequency of mutated trinucleotides in a given cancer sample,
Rebecca C Poulos +4 more
doaj +1 more source
Nature Communications, 2021 Intratumour heterogeneity (ITH) and mutational signatures are typically analysed separately, even though they are not necessarily independent. Here, the authors present CloneSig, a tool for the joint estimation of ITH and mutational signatures, with ...
Judith Abécassis +2 more
doaj +1 more source
Robust monomer-distribution biosignatures in evolving digital biota [PDF]
, 2011 Because organisms synthesize component molecules at rates that reflect those molecules' adaptive utility, we expect a population of biota to leave a distinctive chemical signature on their environment that is anomalous given the local (abiotic) chemistry.
Abelson P.H. +3 more
core +3 more sources
Portrait of a cancer: mutational signature analyses for cancer diagnostics
BMC Cancer, 2019 Background In the past decade, systematic and comprehensive analyses of cancer genomes have identified cancer driver genes and revealed unprecedented insight into the molecular mechanisms underlying the initiation and progression of cancer. These studies
Arne Van Hoeck +3 more
doaj +1 more source
Identification of multiplicatively acting modulatory mutational signatures in cancer
BMC Bioinformatics, 2022 Background A deep understanding of carcinogenesis at the DNA level underpins many advances in cancer prevention and treatment. Mutational signatures provide a breakthrough conceptualisation, as well as an analysis framework, that can be used to build ...
Dovydas Kičiatovas +7 more
doaj +1 more source
The mutational signature of chronic lymphocytic leukemia [PDF]
Biochemical Journal, 2016 Advances in next-generation sequencing technologies continue to unravel the cancer genome, identifying key biological pathways important for disease pathogenesis and clinically relevant genetic lesions. These studies have provided unprecedented resolution of the cancer genome, facilitating significant advances in the ability to detect many cancers, and
Helen, Parker, Jonathan C, Strefford
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
BMC Genomics, 2018 Background Esophageal squamous cell carcinomas (ESCC) is the fourth most lethal cancer in China. Previous studies reveal several highly conserved mutational processes in ESCC.
Jintao Guo +11 more
doaj +1 more source