Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The OECD Dispute Resolution System in Tax Controversies
The article analyses the latest international tax law developments in dispute resolution settlement protocols and the need for effective multilateral solutions to prevent international double taxation.
Marco Greggi, Anna Miotto
doaj +1 more source
STUDY ABOUT THE DEGREE OF KNOWLEDGE OF THE MEDIATION PROCEDURE AMONG THE RESIDENTS OF RURAL COMMUNITIES IN THE SOUTH MUNTENIA DEVELOPMENT REGION, ROMANIA [PDF]
Interhuman relations have experienced many moments of peace, which have favored the emergence of progress, but also moments of unrest, which have led to the emergence of tense phases. It was therefore necessary to develop measures and procedures to bring
Felix Dimitrie CIOCAN +2 more
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
DIVORCE BY MUTUAL AGREEMENT AND NOTARY
Divorce by mutual agreement is subject to a court procedure, but in most countries a notarial procedure is applied in the case of a consensual divorce. In this article, the topic of discussion is a conventional divorce, which is characterized by the fact
Tanja Mitrović S.
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Systematic Design Method for Mutual Coupling Reduction in Closely Spaced Patch Antennas
In this article, a systematic design approach is presented to reduce the mutual coupling between a pair of closely spaced microstrip patch antennas (MPAs).
Hui Deng, Lei Zhu, Zhao-An Ouyang
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
5G-IPAKA: An Improved Primary Authentication and Key Agreement Protocol for 5G Networks
The 3rd generation partnership project (3GPP) has been enhancing the security of the 5G AKA (authentication and key agreement) protocol. However, there may still be some shortcomings in the latest version of the 5G AKA protocol. According to the analysis
Yuelei Xiao, Yang Wu
doaj +1 more source

