Results 51 to 60 of about 3,691,534 (291)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Systematic Design Method for Mutual Coupling Reduction in Closely Spaced Patch Antennas
IEEE Open Journal of Antennas and Propagation, 2023 In this article, a systematic design approach is presented to reduce the mutual coupling between a pair of closely spaced microstrip patch antennas (MPAs).
Hui Deng, Lei Zhu, Zhao-An Ouyang
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
5G-IPAKA: An Improved Primary Authentication and Key Agreement Protocol for 5G Networks
Information, 2022 The 3rd generation partnership project (3GPP) has been enhancing the security of the 5G AKA (authentication and key agreement) protocol. However, there may still be some shortcomings in the latest version of the 5G AKA protocol. According to the analysis
Yuelei Xiao, Yang Wu
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
CONSIDERATIONS REGARDING THE DIVORCE BY AGREEMENT OF THE SPOUSES, ACCORDING TO THE NOTARY PROCEDURE [PDF]
Challenges of the Knowledge Society, 2011 By amending the Family Code according to the provisions of the Law no. 202/2010 regarding some measures in order to speed the solving of processes (“Law of small reform”), representing the introduction to the New Civil Code adopted by the Law no.
ANCA-ANDREEA NISTOREANU
doaj
Problematika Wakaf dan Penyelesaiannya di Pesantren Al-Falah Limboto Barat Kabupaten Gorontalo
Al-Mizan, 2020 This study aims to uncover the problem of waqf and its solution at Pesantren Al-Falah Limboto Gorontalo. This research is field research, which is descriptive of analytical with the primer data and sekunder data.
Tarnima Zakiyah Rini +1 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A comparative study of the procedures for medicine approval in the European Union and the United States [PDF]
Arhiv za farmacijuMedicine registration refers to evaluating a medical product's safety, efficacy, and quality, leading to the granting of a Marketing Authorization. Given the intense globalization of the pharmaceutical industry, harmonizing regulatory procedures between ...
Gjeorgiev Blagoj +6 more
doaj +1 more source