Results 81 to 90 of about 672,642 (313)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Extradition Process in Transnasional Criminal Act to Find Perpetrators

Mimbar, 2016
In some research, it is elaborated that the process of extradition, MLA, Good Mutual Relation are conducted between governments represented by central authority from each state, meanwhile the process of Handing-Over is conducted by police (Ncb-Interpol ...
Muhamad Rakhmat
doaj  

Results From a Patient Experience Study in Pediatric Gastrointestinal Endoscopy

Journal of Patient Experience, 2015
Objective: Gastrointestinal endoscopy in children has become a standard diagnostic and therapeutic modality. The aim of our study was to characterize the most memorable elements of the patient experience from the parent’s and patient’s perspective and ...
Divya Ann Jacob MBBS, Linda Franklin LPN, Bruce Bernstein PhD, Harpreet Pall MD   +3 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Mechanism of external assessment of engineering education programs of Iran

آموزش مهندسی ایران, 2015
In the last two or three decades a global move was formed to revaluate engineering education and accreditation of its outcomes. The main principle in all these efforts was paying less attention to entries (what university offers) and put more attention ...
Hossein Memarian
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Optimization of Ultrasound-assisted Enzymatic Polysaccharide Extraction from Turpiniae Folium Based on Response Surface Methodology

Digital Chinese Medicine, 2018
: Objective To optimize the extraction procedure and obtain the maximum total polysaccharide yield from Turpiniae Folium.Methods Response surface methodology (RSM), combining Plackett–Burman design (PBD), steepest ascent method, and Box–Behnken design ...
Ling-Jia ZHAO, Bo-Hou XIA, Li-Mei LIN, Su-Hui XIONG, Jie TANG, Duan-Fang LIAO   +5 more
doaj   +1 more source

Tinjauan Yuridis Kredit Tanpa Agunan Di Bank Bpr Ukabima Bmms Jogonalan (Studi Kasus Di Klaten) [PDF]

, 2016
Purpose of the research is to know legal construction of unsecured loan agreement, emerging problems, and settlement procedure of the agreement in BPR UKABIMA BMMS Jogonalan. The research is descriptive one with juridical empiric method.
, Septarina Budiwati, S.H., M.H, Prabowosiwi, Muhammad   +1 more
core  

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source