Results 121 to 130 of about 1,330,365 (275)
Towards molecular systems biology of gene transcription and regulation [PDF]
, 2010 Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, P., Cramer, Patrick
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro +14 more
wiley +1 more source
TarO : a target optimisation system for structural biology [PDF]
, 2008 This work was funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) Structural Proteomics of Rational Targets (SPoRT) initiative, (Grant BBS/B/14434).
Naismith, Jim +44 more
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Parasite-Microbiota Interactions With the Vertebrate Gut: Synthesis Through an Ecological Lens
Frontiers in Microbiology, 2018 The vertebrate gut teems with a large, diverse, and dynamic bacterial community that has pervasive effects on gut physiology, metabolism, and immunity.
Jacqueline M. Leung +2 more
doaj +1 more source
The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti +5 more
wiley +1 more source
Building a path in cell biology
, 2012 Setting up a new lab is an exciting but challenging prospect. We discuss our experiences in finding a path to tackle some of the key current questions in cell biology and the hurdles that we have encountered along the ...
Cheeseman, Iain M, Voeltz, Gia
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Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
Tipping Points in Seed Dispersal Mutualism Driven by Environmental Stochasticity [PDF]
The mechanism of seed dispersal mutualism is fundamental to understanding vegetation diversity and its conservation. In this study, we propose a stochastic model that extends the classical framework of seed dispersal mutualism to explore the effects of ...
Qiu, Zhipeng, Feng, Tao, Wang, Hao
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Were Malagasy Uncarina fruits dispersed by the extinct elephant bird?
South African Journal of Science, 2009 We hypothesise that the spiny fruits of the endemic Madagascar genus Uncarina (Pedaliaceae) are trample burrs that evolved to be dispersed on the feet of the extinct elephant bird (Aepyornis).
J. Midgley, N. Illing
doaj
Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad +22 more
wiley +1 more source