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Causal Association Between Immune Cell Traits and Risk of Multiple Malignant and Nonmalignant CNS Diseases: A Mendelian Randomization and Single‐Cell Transcriptomic Analysis

open access: yesBrain and Behavior, Volume 15, Issue 8, August 2025.
This is the graph abstract of our manuscript delineating the methods employed in both MR and scRNA‐seq analyses within the present investigation. ABSTRACT Background The influence of immune cell traits (ICTs) on the onset of multiple brain diseases has been previously investigated; however, it is limited by the sample size or colocalization evidence ...
Shanbao Ke   +3 more
wiley   +1 more source

Familial Autoimmune Myasthenia Gravis (Report Of 3 Cases)

open access: yesAnnals of Indian Academy of Neurology, 2003
Familial Autoimmune myasthenia gravis is rare, occurring in only about 1.3% cases of myasthenia gravis (MG). Here in we report a family with three family members affected by MG. Proband presented with generalised myasthenia where as the other two
Girija A. S, Madhukar M, John John K
doaj  

Megaesófago por Miastenia gravis adquirida en un bóxer [PDF]

open access: yes, 2014
La misatenia gravis (MG) es una enfermedad autoinmune, se presenta con frecuencia en perros; uno de los hallazgos que se asocian a la enfermedad es el megaesofago, es indispensable a través del conocimiento clínico de la enfermedad y la realización de ...
Díaz González, Vieyra Sandra   +3 more
core  

Exploring the Causal Relationship Between Inflammatory Bowel Disease and Bell's Palsy Based on Inflammatory Proteins: A Mendelian Randomization Study

open access: yesBrain and Behavior, Volume 15, Issue 8, August 2025.
Inflammatory bowel diseasemay be a risk factor for Bell's palsy at the genetic level. CXCL5, IL_17C, and SLAMF1 are possible co‐acting pathways between Bell's palsy and inflammatory bowel disease. ABSTRACT Background The relationship between inflammatory bowel disease (IBD) and Bell's palsy remains unsubstantiated.
Daofeng Fan   +7 more
wiley   +1 more source

Single‐cell atlas reveals heterogeneous response to FcRn blockade in anti‐AChR antibody‐positive generalised myasthenia gravis

open access: yesClinical and Translational Medicine, Volume 15, Issue 8, August 2025.
• Aberrant B cells and pro‐inflammatory T cells contribute critically to generalised myasthenia gravis (gMG) pathogenesis. • Neonatal Fc receptor (FcRn) blockade induces immunoglobulin G (IgG) depletion feedback, reflected by increased class‐switched BCRs. • Th17 cell proliferation is attenuated following FcRn blockade.
Hui‐Ning Li   +10 more
wiley   +1 more source

Immune Checkpoint Inhibitors and Cardiovascular Adverse Events

open access: yesESC Heart Failure, Volume 12, Issue 4, Page 2404-2416, August 2025.
Abstract In the last years, we assisted to a tremendous increase in therapeutic options for the management of cancers, with immunotherapy at the forefront of this innovation. Immune checkpoint inhibitors (ICIs) have been developed to enhance the activity of the immune system against cancer cells (1) and the number of approvals for ICIs has rapidly ...
Maria Luisa De Perna   +4 more
wiley   +1 more source

Myasthenia gravis with Castleman disease: A case report with review of literature

open access: yesIndian Journal of Pathology and Microbiology
Myasthenia gravis is an autoimmune disorder caused by the formation of autoantibodies directed against the synapses of neuromuscular junction. It is most commonly associated with other non-thymomatous lesions. Castleman disease is one of them, which is a
Sujit Nandy   +3 more
doaj   +1 more source

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