Results 111 to 120 of about 9,138 (204)

Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene

BMC Medical Genetics, 2008
Background Mutations in MYBPC3 encoding myosin binding protein C belong to the most frequent causes of hypertrophic cardiomyopathy (HCM) and may also lead to dilated cardiomyopathy (DCM).
Lehrke Stephanie, Zeller Raphael, Pribe Regina, Steen Henning, Zehelein Jörg, Weichenhan Dieter, Ehlermann Philipp, Zugck Christian, Ivandic Boris T, Katus Hugo A   +9 more
doaj   +1 more source

RFeusenarcchtional polymorphisms in genes of the Angiotensin and Serotonin systems and risk of hypertrophic cardiomyopathy: AT1R as a potential modifier [PDF]

, 2011
Background: Angiotensin and serotonin have been identified as inducers of cardiac hypertrophy. DNA polymorphisms at the genes encoding components of the angiotensin and serotonin systems have been associated with the risk of developing cardiovascular ...
Berrazueta, J.R. (José), Corao, A.I. (Ana), Coto, Eliecer, Díaz, Marta, García, Cristina, García, Mónica, Martín, María, Morales, Blanca, Morís, César, Ortega, Francisco, Palacín, María, Reguero, J.R. (Julián), Tavira, Beatriz, Álvarez, Victoria   +13 more
core  

Valsartan for attenuating disease evolution in early sarcomeric hypertrophic cardiomyopathy: the design of the Valsartan for Attenuating Disease Evolution in Early Sarcomeric Hypertrophic Cardiomyopathy (VANISH) trial [PDF]

, 2017
Background: Hypertrophic cardiomyopathy (HCM) is often caused by sarcomere gene mutations, resulting in left ventricular hypertrophy (LVH), myocardial fibrosis, and increased risk of sudden cardiac death and heart failure.
Braunwald, Eugene, Cirino, Allison L., Colan, Steven D., Day, Sharlene M., Desai, Akshay S., Ho, Carolyn Y., Lipshultz, Steven E., MacRae, Calum A., McMurray, John J.V., Orav, E. John, Shi, Ling, Solomon, Scott D.   +11 more
core   +1 more source

Single Cell Transcriptomic Profiling of MYBPC3‐Associated Hypertrophic Cardiomyopathy Across Species Reveals Conservation of Biological Process But Not Gene Expression

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Hypertrophic cardiomyopathy (HCM) is a common heritable heart disease where the most frequently associated mutations occur in the myosin‐binding protein C (MYBPC3) sarcomere‐associated gene.
Samia A. Ali, Gayani Perera, Jason Laird, Rebecca Batorsky, Martin S. Maron, Victor N. Rivas, Joshua A. Stern, Samantha Harris, Michael T. Chin   +8 more
doaj   +1 more source

Non-compaction cardiomyopathy – brief review [PDF]

, 2017
Left ventricular non-compaction cardiomyopathy is a genetic disorder characterized by the presence of two myocardial layers with numerous prominent trabeculations and deep inter-trabecular recesses that communicate with the ventricular cavity.
Berceanu, Mihaela, Constantin, Anca, Donoiu, Ionuț, Istrătoaie, Octavian, Militaru, Constantin, Mirea, Oana, Mănescu, Mirela, Târtea, Georgică Costinel   +7 more
core   +3 more sources

Novel mutation associated with non‐compaction ventricular myocardium: A case report

ESC Heart Failure, Volume 12, Issue 6, Page 4548-4554, December 2025.
Yan Li, Xi Wang, Saiyong Chen, Chun Wu, Fushi Piao   +4 more
wiley   +1 more source

Evaluation of a polymorphism in MYBPC3 in patients with anthracycline induced cardiotoxicity

Indian Heart Journal, 2018
Cardiotoxicity is the most serious side effect of anthracyclines (doxorubicin, daunorubicin or epirubicin). The incidence of anthracycline induced late cardiac toxicity (AIC) that is overt clinically is 3–5% in the Indian population.
M. Thirumalai Vinodhini, S. Sneha, R.P. Nagare, S. Bindhya, V. Shetty, D. Manikandan, P. Ganesan, T.G. Sagar, T.S. Ganesan   +8 more
doaj   +1 more source

Functional polymorphisms in genes of the Angiotensin and Serotonin systems and risk of hypertrophic cardiomyopathy: AT1R as a potential modifier [PDF]

, 2013
Background: Angiotensin and serotonin have been identified as inducers of cardiac hypertrophy. DNA polymorphisms at the genes encoding components of the angiotensin and serotonin systems have been associated with the risk of developing cardiovascular ...
Berrazueta, J.R. (José), Castro, M.G. (Mónica), Corao, A.I. (Ana), Coto, Eliecer, Díaz, Marta, García, Cristina, Martín, María, Morales, Blanca, Morís, César, Ortega, Francisco, Palacín, María, Reguero, J.R. (Julián), Tavira, Beatriz, Álvarez, Victoria   +13 more
core  

Is MYBPC3 linked to bicuspid aortic valve? [PDF]

Translational Pediatrics, 2021
Niaz, Talha, Hagler, Donald J.
openaire   +2 more sources

High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant

Journal of Molecular Biomarkers & Diagnosis, 2016
A 25-basepair deletion variant of MYBPC3 occurs at high frequency in individuals of South Asian descent and is estimated to affect 55 million people worldwide, carrying an increased likelihood of cardiomyopathy. Since this variant is prevalent and severe in this subpopulation, quick and affordable screening to provide risk-assessment to guide treatment
Barefield, David Y, Lynch, Thomas L, Jagadeesan, Aravindakshan, Sanagala, Thriveni, Sadayappan, Sakthivel   +4 more
openaire   +2 more sources