Results 81 to 90 of about 7,387 (194)
Polymorphism on Myh7 and Mybpc3 Genes between B6 and D2 Strains.
, 2015 Polymorphism on Myh7 and Mybpc3 Genes between B6 and D2 Strains.
Yuanjian Chen (779441) +8 more
core +1 more source
MYBPC3 Gene Therapy for Neonatal Sarcomeric Cardiomyopathies [PDF]
Biophysical Journal, 2015 Hypertrophic cardiomyopathy (HCM) is mainly characterized by left ventricular hypertrophy (LVH), diastolic dysfunction and increased interstitial fibrosis. HCM has an estimated prevalence in a young adult population of 1:500 and is the leading cause of sudden cardiac death in young athletes. HCM is transmitted in an autosomal-dominant fashion and often
openaire +1 more source
Genetic determinants of clinical phenotype in hypertrophic cardiomyopathy
BMC Cardiovascular Disorders, 2020 Background Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease that affects approximately one in 500 people. HCM is a recognized genetic disorder most often caused by mutations involving myosin-binding protein C (MYBPC3)
Lazar Velicki +17 more
doaj +1 more source
Human c-MYBPC3 RNA Targeted Therapy, Reversal of Hypertrophic Cardiomyopathy in the Zebrafish Model [PDF]
, 2016 Hypertrophic cardiomyopathy (HCM) is a serious heart disease and is defined as abnormal left ventricular (LV) wall thickening with diastolic dysfunction.
Da'As, Sahar +5 more
core +1 more source
PLoS ONE, 2023 Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats with a suspected genetic origin. Previous studies have identified five HCM-associated variants in three genes (Myosin binding protein C3: MYBPC3 p.A31P, p.A74T, p.R820W; Myosin ...
Noriyoshi Akiyama +5 more
doaj +1 more source
Clinical Genetics, Volume 110, Issue 5, Page 622-626, November 2026.Pediatric cardiomyopathies (CM) are a heterogeneous group of disorders. Their genetic basis remains poorly defined, particularly in children with early‐onset and apparently isolated forms. With a diagnostic yield of 62.7%, our findings suggest that whole‐exome sequencing could improve the diagnosis, genetic counseling, and clinical management of ...
Luana Giovannangeli +18 more
wiley +1 more source
MYBPC3-associated cardiomyopathy: features of the course and prospects for specific therapy
Кардиоваскулярная терапия и профилактикаGenetic cardiomyopathies (CMP) are a group of diseases characterized by myocardial pathology not caused by hypertension, coronary artery disease, congenital and acquired defects.
D. A. Nefedova +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 55, 5 October 2026.In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor +11 more
wiley +1 more source
Functional analysis of a new splicing mutation in the MYBPC3 gene in hypertrophic cardiomyopathy
Бюллетень сибирской медициныAim. To study the pathogenic effect in the MYBPC3 splice-site variant in the patient with hypertrophic cardiomyopathy. Materials and methods. The study was conducted using a DNA sample obtained from a patient with hypertrophic cardiomyopathy, in whom a ...
R. R. Salakhov +6 more
doaj +1 more source
Clinical Cardiology, Volume 49, Issue 10, October 2026.Genomic medicine in cardiovascular care is progressing from established diagnostic applications toward integrated risk prediction, multiomics, and emerging therapeutic strategies. ABSTRACT Background Genomic cardiology is an emerging field integrating genetic, molecular, imaging, and digital health data to improve cardiovascular disease (CVD ...
Neda Mohsen‐Pour +5 more
wiley +1 more source