Results 61 to 70 of about 1,519 (167)

Draft Genome Sequence of Mycobacterium chimaera Type Strain Fl-0169

, 2017
We report here the draft genome sequence of the type strain Mycobacterium chimaera Fl-0169, a member of the Mycobacterium avium complex (MAC). M. chimaera Fl-0169 T
Vasily Tokarev, Vicente Gomez-Alvarez, Dawn King, Regina Lamendella, Collin Kessler, Christopher McLimans, Stacy Pfaller, Justin Wright   +7 more
core   +1 more source

Target-Specific Assay for Rapid and Quantitative Detection of Mycobacterium chimaera DNA

, 2017
Mycobacterium chimaera is an opportunistic environmental mycobacterium belonging to the Mycobacterium avium - M. intracellulare complex. Although most commonly associated with pulmonary disease,
Janet A. M. Fyfe, Andrew J. Stewardson, Timothy P. Stinear, Enrique Zozaya-Valdés, Glen P. Carter, Anders Gonçalves da Silva, Mark B. Schultz, Deborah A. Williamson, Ivan Bastian, John Coventry, Torsten Seemann, Benjamin P. Howden, Paul D. R. Johnson, Jessica L. Porter, Sally A. Roberts   +14 more
core   +2 more sources

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Immune reconstitution inflammatory syndrome in Mycobacterium chimaera mediastinitis: When clinical judgment trumps imaging

International Journal of Mycobacteriology, 2021
Mycobacterium chimaera has been described in postoperative cardiovascular procedures in patients after an outbreak of contaminated 3T heater–cooler units.
Sara Haddad, Ralph Tayyar, Lawrence Livornese Jr, Leah Lande, Jerome Santoro   +4 more
doaj   +1 more source

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3

The FEBS Journal, EarlyView.
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova, Anna N. Khusnutdinova, Hairong Ma, Manuel Ferrer, Olga V. Golyshina, Alexander F. Yakunin, Peter N. Golyshin   +6 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Mycobacterium chimaera – a new threat for cardiac surgical patients?

Polish Journal of Cardio-Thoracic Surgery, 2017
An outbreak of invasive Mycobacterium chimaera infections associated with "heater-cooler" devices in patients treated with cardiac surgery has been described worldwide. The authors summarize the current state of knowledge regarding the epidemiology, diagnostics, treatment, and prevention of Mycobacterium chimaera infections in patients after ...
Jaworski, Radosław, Naumiuk, Łukasz, Paczkowski, Konrad, Formella, Danuta, Pek, Renata, Zieliński, Jacek, Haponiuk, Ireneusz   +6 more
openaire   +2 more sources

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, EarlyView.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

A single-center experience with microbiologic surveillance of LivaNova 3T heater-cooler devices (HCDs)

Antimicrobial Stewardship & Healthcare Epidemiology, 2023
Background: The global outbreak of Mycobacterium chimaera infections associated with HCDs resulted in new maintenance recommendations. Since 2018, HCDs have been disinfected according to instructions for use (IFU), including twice-monthly bleach ...
Scott Curry, Yosra Alkabab, Danny Nixon, Susan Dorman, Cassandra Salgado   +4 more
doaj   +1 more source

Semi‐Rational Engineering of Formate Dehydrogenase Reveals Loop Dynamics as a Key Determinant of Thermostability

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Semi‐rational engineering yields a thermostable Bacillus simplex formate dehydrogenase variant (Q125F) with a 25‐fold longer half‐life at 60°C and strong resistance to chemo‐inactivation. Molecular dynamics reveal enhanced π–π interactions stabilizing a flexible loop and enabling efficient NADH regeneration for robust biocatalytic detoxification ...
Rattima Boonkumkrong, Sahachat Soithongcharoen, Pitchayathida Mee‐udorn, Paweenapon Chunthaboon, Somchart Maenpuen, Thanyada Rungrotmongkol, Pratchaya Watthaisong, Ruchanok Tinikul   +7 more
wiley   +1 more source