Results 91 to 100 of about 187,712 (288)

Faktor-Faktor yang Mempengaruhi Terjadinya Infeksi Kusta

JKS (Jurnal Kedokteran Syiah Kuala), 2010
Abstrak.  Program pemberantasan kusta di dunia telah berjalan Jebih dari 20 tahun terakhir, namun kasus insiden kusta baru tidak menurun. Dengan kata lain penularan penyakit kusta masih terus terjadi di rnana- mana.
Mudatsir Mudatsir
doaj  

Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis.

PLoS Neglected Tropical Diseases, 2022
Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae, an obligate intracellular bacterium. Timely detection is a challenge in leprosy diagnosis, relying on clinical examination and trained health professionals.
Fernanda Saloum de Neves Manta, Thiago Jacomasso, Rita de Cássia Pontello Rampazzo, Suelen Justo Maria Moreira, Najua M Zahra, Stewart T Cole, Charlotte Avanzi, Thyago Leal-Calvo, Sidra Ezidio Gonçalves Vasconcellos, Phillip Suffys, Marcelo Ribeiro-Alves, Marco Aurelio Krieger, Alexandre Dias Tavares Costa, Milton Ozório Moraes   +13 more
doaj   +1 more source

Skeletal Evidence for Leprosy in India by the Second Millenium B.C. [PDF]

, 2009
Leprosy is a chronic infectious disease caused by _Mycobacterium leprae_ that affects almost 500,000 people worldwide^1^. The timing of first infection, geographic origin, and pattern of transmission of the disease are unknown^1-3^.
Gwendolyn Robbins, Kelsey Gray, Malcolm Schug, RK Mohanty, Veena Tripathy, VN Misra, VS Shinde   +6 more
core   +1 more source

The Activity of a Thiadiazole on Mycobacterium leprae

Experimental Biology and Medicine, 1976
SummaryA new broad-spectrum antimicrobial, 2-amino-5-(l-methyl-5-nitro-2-imi-dazolyl)-1,3,4-thiadiazole, reported inactive against Mycobacterium tuberculosis, inhibited multiplication of M. leprae in the mouse foot pad when administered orally to the mice.
openaire   +3 more sources

Studies of Lipoproteins of Mycobacterium leprae

Japanese journal of leprosy, 2004
The deciphering of the genomic sequence of Mycobacterium leprae has made possible to predict the possible lipoproteins. The consensus sequence at the N-terminal region of the protein, including the cysteine residue to which the lipid moiety gets attached, provides a clue to the search.
Yumi Maeda, Masahiko Makino, Patrick J. Brennan   +2 more
openaire   +3 more sources

Estimating the Effective Population Size Across Space and Time in the Critically Endangered Western Chimpanzee in Guinea‐Bissau: Challenges and Implications for Conservation Management

Evolutionary Applications, Volume 18, Issue 10, October 2025.
ABSTRACT The western chimpanzee (Pan troglodytes verus) is a Critically Endangered taxon. In Guinea‐Bissau (GB), the subspecies is increasingly threatened, but there is a lack of understanding regarding the degree of genetic threat faced by populations.
Maria Joana Ferreira da Silva, Filipa Borges, Federica Gerini, Rui M. Sá, Francisco Silva, Tiago Maié, Germán Hernández‐Alonso, Jazmín Ramos‐Madrigal, Shyam Gopalakrishnan, Isa Aleixo‐Pais, Saidil Lamine Djaló, Nelson Fernandes, Idrissa Camará, Aissa Regalla, Catarina Casanova, Mafalda Costa, Ivo Colmonero‐Costeira, Carlos Rodríguez Fernandes, Lounès Chikhi, Tânia Minhós, Michael W. Bruford   +20 more
wiley   +1 more source

Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor

The FEBS Journal, Volume 292, Issue 19, Page 5234-5243, October 2025.
The adenylyl cyclase (AC) Rv1625c from M. tuberculosis is a monomeric progenitor of the nine pseudoheterodimeric mammalian AC isoforms. The hexahelical membrane anchor of Rv1625c serves as an inhibitory receptor for fatty acids, particularly oleic acid. One ligand binds into each monomer of the active Rv1625c dimer.
Anita Charlotte Friderun Schultz, Marius Landau, Andrei N. Lupas, Joachim Erdmann Schultz   +3 more
wiley   +1 more source

M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression

BMC Microbiology, 2006
Background Virulent Mycobacterium leprae interfere with host defense mechanisms such as cytokine activation and apoptosis. The mitochondrial pathway of apoptosis is regulated by the Bcl-2 family of proteins.
Tayyebi Ali, Ashraf Mussarat, Hasan Zahra, Hussain Rabia   +3 more
doaj   +1 more source

Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae

Infection and Immunity, 2016
The innate immune system recognizes microbial pathogens via pattern recognition receptors. One such receptor, NOD2, via recognition of muramyl dipeptide (MDP), triggers a distinct network of innate immune responses, including the production of ...
M. Schenk, S. Mahapatra, Phuonganh Le, H. Kim, Aaron W. Choi, P. Brennan, J. Belisle, R. Modlin   +7 more
semanticscholar   +1 more source

Adjuvant Activity of Mycobacterium leprae [PDF]

Infection and Immunity, 1972
Mycobacterium leprae organisms isolated from infected spleen and liver tissue by zonal centrifugation were shown to possess adjuvant activity. Histochemical examination of the footpad macrophage epithelioid granuloma showed that macrophages contained large amounts of hemosiderin after the injection of M. leprae
M. Davies, D. E. S. Stewart-Tull
openaire   +3 more sources