Results 291 to 300 of about 4,993,363 (331)
Some of the next articles are maybe not open access.
Antifibrotic actions of mycophenolic acid
Clinical Transplantation, 2006Abstract: Mycophenolic acid (MPA) is a highly selective, non‐competitive and reversible inhibitor of the inosine monophosphate dehydrogenase (IMPDH), the rate‐limiting enzyme in the de novo biosynthesis of guanosine nucleotides. Mycophenolate mofetil (MMF, the ester prodrug of MPA) strongly inhibits both T‐ and B‐lymphocyte proliferation and has now ...
Jörg Beimler +6 more
openaire +3 more sources
Blood Distribution of Mycophenolic Acid
Therapeutic Drug Monitoring, 1994RS-61443 (RS) a morpholinoethyl ester of mycophenolic acid (MPA), can be considered a prodrug, as immunosuppressive activity is expressed only after hydrolysis to MPA upon absorption. Little is known about the blood distribution of MPA; such information would have an impact on the medium used for analysis of the drug in clinical trials.
Loralie J. Langman +2 more
openaire +3 more sources
Analogues of mycophenolic acid
Bioorganic Chemistry, 1975Abstract Analogues of mycophenolic acid were produced by cultures of Penicillium brevi-compactum fed, respectively, with 4,6-dihydroxycoumaran-3-one, 5,7-dihydroxyindan-1-one, and 2,4-dihydroxyacetophenone.
R. Craveri +5 more
openaire +2 more sources
A reinvestigation of the demethylation of mycophenolic acid
Tetrahedron, 1969Abstract The reaction of mycophenolic acid (I, R = Me, R1 = H) with hydriodic acid has been shown to give the isomeric chromans (II and III) and the lactone IV. Chroman II was previously thought to be desmethylmycophenolic acid (I, R, R1 = H). With hydriodic acid both chromans, (II and III) give a similar equilibrium mixture.
T.P. Seden, W.B. Turner, R.W. Turner
openaire +3 more sources
New Analogues of Mycophenolic Acid
Mini-Reviews in Medicinal Chemistry, 2017Mycophenolic acid (MPA) possesses antibacterial, antifungal, antiviral, immunosuppressive and anticancer properties. It is a non-competitive and reversible inhibitor of dehydrogenase inosine-5'-monophosphate (IMPDH). This compound belongs to the immunosuppressive drugs used for the prevention of both acute and chronic transplant rejection.
Agnieszka Siebert +3 more
openaire +3 more sources
Derivatives of mycophenolic acid
Australian Journal of Chemistry, 1978Derivatives of mycophenolic acid and of mycochromenic acid are reported. These compounds include a relatively stable tertiary iodide.
openaire +4 more sources
ChemInform Abstract: The Synthesis of Mycophenolic Acid.
ChemInform, 1993AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire +3 more sources
Journal of clinical pharmacology, 2019
Mycophenolic acid (MPA) is an immunosuppressive agent commonly prescribed during posttransplant periods for the prevention of acute and chronic rejection following organ transplantation. Compelling evidence has demonstrated a pivotal role of the exposure
Juthipong Benjanuwattra +2 more
semanticscholar +1 more source
Mycophenolic acid (MPA) is an immunosuppressive agent commonly prescribed during posttransplant periods for the prevention of acute and chronic rejection following organ transplantation. Compelling evidence has demonstrated a pivotal role of the exposure
Juthipong Benjanuwattra +2 more
semanticscholar +1 more source
Therapeutic Drug Monitoring, 1999
A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of mycophenolic acid and its metabolite, mycophenolic acid glucuronide, is presented herein. Sample purification is limited to protein precipitation with acetonitrile.
Christina Brattström +2 more
openaire +3 more sources
A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of mycophenolic acid and its metabolite, mycophenolic acid glucuronide, is presented herein. Sample purification is limited to protein precipitation with acetonitrile.
Christina Brattström +2 more
openaire +3 more sources
A total synthesis of mycophenolic acid
Journal of the Chemical Society D: Chemical Communications, 1969Mycophenolic acid (I) has been synthesized by a method adaptable to the synthesis of analogues and of possible biogenetic intermediates. The aromatic nucleus was elaborated by a novel application of the Alder- Rickert dime synthesis.
A. J. Birch, J. J. Wright
openaire +3 more sources