Results 311 to 320 of about 4,993,363 (331)
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Total synthesis of mycophenolic acid
Tetrahedron, 2003Abstract A convergent total synthesis of the natural compound mycophenolic acid 1 is described. The synthetic strategy for the construction of the hexasubstituted aromatic nucleus was based on a ring annulation sequence, involving a Michael addition reaction and intramolecular Dieckmann condensation reaction in situ as the key step.
Adrián Covarrubias-Zúñiga +2 more
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Pharmacokinetics of Mycophenolic Acid in Renal Insufficiency
Therapeutic Drug Monitoring, 2000Mycophenolate mofetil (MMF) is now widely used in solid organ transplantation. MMF is rapidly converted to its active form, mycophenolic acid (MPA), upon reaching the systemic circulation. MPA is metabolized to its glucuronide metabolite, mycophenolic acid glucuronide (MPAG), by glucoronyl transferases in the liver and possibly elsewhere.
Leslie M. Shaw +3 more
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Mycophenolic acid as a latent agonist of PPARγ
Bioorganic & Medicinal Chemistry Letters, 2007Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated ...
Mie Tsuruga +10 more
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Optimization Strategies for Purification of Mycophenolic Acid Produced by Penicillium brevicompactum
Applied Biochemistry and Biotechnology, 2020S. Anand, P. Srivastava
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Therapeutic potential and molecular mechanisms of mycophenolic acid as an anticancer agent.
European Journal of Pharmacology, 2020Juthipong Benjanuwattra +3 more
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Mechanisms of Action of Mycophenolic Acid
Annals of the New York Academy of Sciences, 1993Anthony C. Allison +3 more
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Mycophenolic acid and mycophenolic acid glucuronide trough levels after renal transplantation
Transplantation Proceedings, 1997R. Pichlmayr, M. Behrend, R. Lueck
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A total synthesis of mycophenolic acid
Tetrahedron Letters, 1971L. Canonica +3 more
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Exposure-Toxicity Relationships of Mycophenolic Acid in Adult Kidney Transplant Patients
Clinical Pharmacokinetics, 2019Tony K. L. Kiang, M. H. Ensom
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