Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran +10 more
wiley +1 more source
Secondary invasive aspergillosis following severe <i>Mycoplasma pneumoniae</i> infection in children: Report of two cases. [PDF]
Yang M +7 more
europepmc +1 more source
pH‐Responsive Ultrasmall Iron Oxide Nanoassemblies for Activatable T2/T1 Magnetic Resonance Imaging
This research reports a pH‐responsive ultrasmall iron oxide nanoparticle (USIONs)/polymer nanoassemblies for activatable magnetic resonance imaging. Amphiphilic diphosphonic acid block copolymers compactly encapsulate USIONs to generate T2‐weighted contrast at physiological pH, while acidic conditions trigger disassembly, activating T1‐weighted ...
Xumin Huang +11 more
wiley +1 more source
Practices and perceptions of antibiotic use in canine breeding: a survey among breeders and veterinarians. [PDF]
Spanoghe L +7 more
europepmc +1 more source
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali +10 more
wiley +1 more source
Comprehensive and innovative post-market surveillance system for atypical respiratory pathogens detecting qPCR panel. [PDF]
Kosińska-Selbi B +9 more
europepmc +1 more source
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito +15 more
wiley +1 more source
S100A8/A9 as a novel predictor for severe Mycoplasma pneumoniae pneumonia in children: A prospective observational study. [PDF]
Liu Z +6 more
europepmc +1 more source
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher +12 more
wiley +1 more source
Characterization of Nasopharyngeal Microbiota Dysbiosis in Children with <i>Mycoplasma pneumoniae</i> Pneumonia. [PDF]
Bi J +9 more
europepmc +1 more source

