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Clinical Genetics, 1977
Routine ophthalmoscopy and fundoscopy of 673 individuals revealed 42 whose irides failed to dilate to a clinically useful degree within 25 to 30 min after the administration of drops of 1% mydracil. These individuals occurred with different frequency among the Aymara, Mestizo, and nonâAymara groups which made up the sample of examinees.
Goldsmith, Robert I. +2 more
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Routine ophthalmoscopy and fundoscopy of 673 individuals revealed 42 whose irides failed to dilate to a clinically useful degree within 25 to 30 min after the administration of drops of 1% mydracil. These individuals occurred with different frequency among the Aymara, Mestizo, and nonâAymara groups which made up the sample of examinees.
Goldsmith, Robert I. +2 more
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European Journal of Pharmacology, 1980
Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 = 8-12 min), intermediate for BW ...
A D, Korczyn, Y, Eshel, O, Keren
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Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 = 8-12 min), intermediate for BW ...
A D, Korczyn, Y, Eshel, O, Keren
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Life Sciences, 1979
Abstract In mice, morphine produces dose-dependent mydriasis. The mydriatic effect does not depend upon the integrity of the sympathetic system, and interference with central catecholamines or serotonin also does not abolish the response. Ro 4-1284, a neurotransmitter depletor, causes miosis and inhibits completely the response to morphine.
A D, Korczyn, R, Boyman, L, Shifter
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Abstract In mice, morphine produces dose-dependent mydriasis. The mydriatic effect does not depend upon the integrity of the sympathetic system, and interference with central catecholamines or serotonin also does not abolish the response. Ro 4-1284, a neurotransmitter depletor, causes miosis and inhibits completely the response to morphine.
A D, Korczyn, R, Boyman, L, Shifter
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Somatostatin mydriasis in mice
Life Sciences, 1983Administration of somatostatin intracerebroventricularly to mice produced a dose-dependent mydriasis, whereas intravenous injections were ineffective. Naloxone could prevent or abolish this effect. It is suggested that somatostatin either directly excites opiate receptors or activates endopioid pathways involved in the regulation of pupillary size.
Y, Eshel, Y, Sarne, A D, Korczyn
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Journal of Ocular Pharmacology and Therapeutics, 1985
In several rodent species pilocarpine and oxotremorine produce mydriasis, rather than the miosis which is characteristic of most other species. We have established that pilocarpine is a mydriatic drug in mice, a species in which the action has previously not been described, and that this effect occurs after local ocular, intraperitoneal (IP) or ...
R, Koval, A D, Korczyn
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In several rodent species pilocarpine and oxotremorine produce mydriasis, rather than the miosis which is characteristic of most other species. We have established that pilocarpine is a mydriatic drug in mice, a species in which the action has previously not been described, and that this effect occurs after local ocular, intraperitoneal (IP) or ...
R, Koval, A D, Korczyn
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Bilateral Congenital Mydriasis
American Journal of Ophthalmology, 1976A 73-year-old white woman with bilateral congenital mydriasis had no other obvious abnormalities. The pupils reacted almost imperceptibly to light. There was no detectable reaction to accommodation and convergence. Pupillary response to pilocarpine 4% solution indicated the presence of the sphincter muscle. However, the failure of the pupil to react to
W C, Caccamise, P L, Townes
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Clonidine mydriasis in the rat
European Journal of Pharmacology, 1979Pupillary responses to clonidine (3--100 micrograms/kg, i.v.) and epinephrine (1--30 micrograms/kg, i.v.) were observed in anesthetized rats. Clonidine caused a dose-dependent mydriasis which was effectively antagonized by pretreatment with yohimbine (1.5 mg/kg, i.v.).
T, Gherezghiher, M C, Koss
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New England Journal of Medicine, 2012
A healthy 3-year old boy was brought to the emergency department because of an acutely dilated right pupil, which developed after he had played in the garden. Half an hour before presentation, his parents noticed he had been crying.
Aaron Vunda, Gabriel Alcoba
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A healthy 3-year old boy was brought to the emergency department because of an acutely dilated right pupil, which developed after he had played in the garden. Half an hour before presentation, his parents noticed he had been crying.
Aaron Vunda, Gabriel Alcoba
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The Mydriasis Provocative Test
Archives of Ophthalmology, 1961Results of provocative testing in angle-closure glaucoma are presumed to depend on mechanical obstruction to the egress of aqueous. 1,2 Recent refinements of this test have hinged on recording a reduction in outflow facility prior to any elevation in intraocular pressure.
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2011
A dilated unreactive pupil is a dramatic clinical finding. While it can be seen in the setting of compressive third nerve palsy, it can also be due to pharmacologic mydriasis. We discuss the approach to the patient with suspected pharmacologic mydriasis, with an emphasis on the role of pharmacologic pupil testing.
Matthew J. Thurtell +2 more
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A dilated unreactive pupil is a dramatic clinical finding. While it can be seen in the setting of compressive third nerve palsy, it can also be due to pharmacologic mydriasis. We discuss the approach to the patient with suspected pharmacologic mydriasis, with an emphasis on the role of pharmacologic pupil testing.
Matthew J. Thurtell +2 more
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