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Myelin Basic Protein and Demyelinating Diseases
CRC Critical Reviews in Clinical Laboratory Sciences, 1986Myelin basic protein (MBP) is a major protein component of myelin sheath. Primarily because of its ability to induce experimental allergic encephalomyelitis (EAE) in animals, this protein has been considered to play an important role in the pathogenesis of multiple sclerosis (MS), which is one of the most common demyelinating diseases.
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A Rapid Method for Purification of Myelin Basic Protein
Journal of Neurochemistry, 1986Abstract: A rapid procedure for purification of myelin basic protein has been developed. White matter is delipidated with 2‐butanol, and the residue is extracted at pH 7.5 and 8.5. Myelin basic protein is solubilized by extraction in acetate buffer, pH 4.5.
BELLINI, Tiziana +3 more
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Myelin basic protein administration in multiple sclerosis.
Archives of Neurology, 1973Sixty-four subjects served in a doubleblind trial to test the efficacy of desensitization to human myelin basic protein (BP) as a therapy in multiple sclerosis.
B. Campbell +3 more
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Specificity of Myelin Basic Proteins
1970A number of studies have appeared in the last ten years on the isolation from central nervous system (CNS) of certain highly basic proteins which are capable of inducing experimental allergic encephalomyelitis (EAE).(1–10) These studies have depended largely on tests of biological activity to monitor the fractionation procedures.
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Conformation of Myelin Basic Protein and Its Role in Myelin Formation
1978High resolution 13C and 1H NMR spectra of myelin basic protein over a range of pH and concentrations indicate that intramolecular folding of the polypeptide chain occurs in aqueous solution in the region of residues 85 to 116. At pH 4 in D2O solution, the 13C resonances due to nonprotonated carbons of phenylalanine and tryptophan are broadened and ...
B. E. Chapman +2 more
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MYELIN BASIC PROTEIN MICROHETEROGENEITY IN SUBFRACTIONS OF RAT BRAIN MYELIN
Journal of Neurochemistry, 1978Abstract— Myelin subfractions were prepared from adult rat brain by discontinuous sucrose gradient ultracentrifugation. Gel electrophoretic studies at pH 10.6 in the presence of urea revealed differences in basic protein microheterogeneity among subfractions.
C. W. Shults +2 more
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Specificity of zinc binding to myelin basic protein
Neurochemical Research, 1995Zn2+ appears to stabilize the myelin sheath but the mechanism of this effect is unknown. In a previous report we have shown that zinc binds to CNS myelin basic protein (MBP) in the presence of phosphate and this results in MBP aggregation. For this paper we used a solid phase zinc blotting assay to identify which myelin proteins bind zinc. MBP and a 58
Riccio P +8 more
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From Myelin Basic Protein to Myelin Deficient Mice
1990In order to control diseases affecting myelination, an understanding of normal myelin structure and its formation is essential. Paradoxically, much information about normal development can be obtained through investigations of hypomyelinated mutants.
J.-M. Matthieu, M. Tosic
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The CSF myelin basic protein in pediatric hydrocephalus
Child's Nervous System, 1994Concentrations of myelin basic protein (MBP) in ventricular and lumbar cerebrospinal fluid (CSF) of 20 pediatric hydrocephalic patients were reviewed. Raised values were found to be particularly significant in children aged more than 1 year. Control measurements after shunt placement showed an important drop in the MBP concentration, which could ...
LONGATTI, PIERLUIGI +4 more
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